内蒙古中东部地区不同来源大肠杆菌耐药性调查

发布时间：2018-09-14 16:12

【摘要】：本研究旨在调查内蒙古赤峰、通辽地区不同来源的大肠杆菌对抗生素类药物的耐药情况。采用K-B法分析来源于鹅、牛和猪等患病动物分离出的46株大肠杆菌对13种常用的抗生素类药物的耐药性;鹅源和猪源大肠杆菌对盐酸多西环素的耐药率最高,分别达95.2%和93.3%;牛源大肠杆菌对盐酸沙拉沙星、恩诺沙星和盐酸多西环素的耐药率最高,达80.0%。多重耐药性结果表明,患病动物的大肠杆菌以6耐(23.9%)为主;牛源大肠杆菌则以7耐(40%)最多。总体耐药谱型以恩诺沙星/氟苯尼考/盐酸多西环素/阿莫西林/硫酸新霉素为主(24.4%)。不同来源的大肠杆菌对抗生素类药物均产生了严重的耐药性,因此不但要求养殖人员学会合理使用抗生素类药物,同时研究开发逆转耐药性的新药物或对抗生素类药物有增敏效用的新药物十分必要。
[Abstract]:The purpose of this study was to investigate the resistance of Escherichia coli from different sources to antibiotics in Chifeng and Tongliao, Inner Mongolia. The resistance of 46 strains of Escherichia coli isolated from geese, cattle and pigs to 13 common antibiotics was analyzed by K-B method, and the resistance rate of geese and porcine Escherichia coli to doxycycline hydrochloride was the highest. The resistance rate of bovine Escherichia coli to salafloxacin hydrochloride, enrofloxacin and doxycycline hydrochloride was the highest (80.0%). The results of multidrug resistance showed that 6 (23. 9%) of E. coli and 7 (40%) of bovine Escherichia coli were the most resistant. Enrofloxacin / florfenicol / doxycycline hydrochloride / amoxicillin / neomycin sulfate were the main drug resistance patterns (24.4%). Escherichia coli from different sources has developed serious drug resistance to antibiotics. Therefore, not only do farmers need to learn how to use antibiotics reasonably, At the same time, it is necessary to develop new drugs that can reverse drug resistance or increase sensitivity to antibiotics.
【作者单位】：内蒙古华天制药有限公司乌兰察布市动物疫病预防控制中心
【基金】：2013年国家中小企业创新基金(13C26211500785)
【分类号】：S852.61

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