饲用L-色氨酸的安全性评价
发布时间：2018-10-18 17:09
【摘要】：L-色氨酸是人体和动物所必需的8种必需氨基酸之一,饲用L-色氨酸为新工艺生产的产品。试验通过小鼠精子畸形试验及小鼠骨髓微核试验来评价饲用L-色氨酸的潜在致突变作用。结果显示,饲用L-色氨酸1.25、2.5、5.0 g/kg体重的三个剂量组与阴性对照组相比,精子畸形率和精子畸形类别百分率无显著差异(P0.05),三个剂量组小鼠骨髓微核率与阴性对照组无显著性差异(P0.05)。结果表明饲用L-色氨酸无明显的体内致突变性。
[Abstract]:L-tryptophan is one of 8 essential amino acids necessary for human and animal. Feed L-tryptophan is a new product. The potential mutagenicity of L-tryptophan was evaluated by sperm malformation test and bone marrow micronucleus test. The results showed that there was no significant difference in sperm malformation rate and percentage of sperm malformation between the three dosage groups and the negative control group (P0.05), but there was no significant difference in micronucleus rate of bone marrow between the three dose groups and the negative control group (P0.05). The results showed that L-tryptophan had no obvious mutagenicity in vivo.
【作者单位】： 扬州大学兽医学院;江苏省动物重要疾病与人兽共患病防控协同创新中心;
【基金】：江苏高校优势学科建设工程项目
【分类号】：S816.7
本文编号：2279809
[Abstract]:L-tryptophan is one of 8 essential amino acids necessary for human and animal. Feed L-tryptophan is a new product. The potential mutagenicity of L-tryptophan was evaluated by sperm malformation test and bone marrow micronucleus test. The results showed that there was no significant difference in sperm malformation rate and percentage of sperm malformation between the three dosage groups and the negative control group (P0.05), but there was no significant difference in micronucleus rate of bone marrow between the three dose groups and the negative control group (P0.05). The results showed that L-tryptophan had no obvious mutagenicity in vivo.
【作者单位】： 扬州大学兽医学院;江苏省动物重要疾病与人兽共患病防控协同创新中心;
【基金】：江苏高校优势学科建设工程项目
【分类号】：S816.7
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