鹿茸完全再生机制研究进展
发布时间：2018-11-14 13:31
【摘要】：鹿茸每年从角柄残桩上完全再生,是目前发现的唯一能够完全再生的哺乳动物器官,是研究自然界哺乳动物肢体/附属器官完全再生问题的理想模型。研究显示,鹿茸芽基来源于角柄骨膜细胞的增殖与分化。角柄骨膜细胞可以表达多种胚胎干细胞标记物并且能够在离体情况下被诱导分化成多种体细胞,为鹿茸干细胞。鹿茸干细胞只有与紧密包裹的角柄皮肤细胞建立起相互作用后才能发起鹿茸的再生。鹿茸早期的再生过程在组织学上与小鼠(Mus musculus)断肢伤口愈合过程相似,区别在于角柄骨膜细胞与长骨骨膜细胞的增殖潜能。有效提高小鼠断肢长骨骨膜细胞的增殖潜能,使之接近角柄骨膜细胞,或许可以实现哺乳动物的肢体部分完全再生。本文综述了鹿茸各组织再生和鹿茸干细胞的研究进展,比较了鹿茸再生与蝾螈(Notophthalmus uiridescens)肢体再生的异同并且对鹿茸再生模型到临床用提出了展望。本文为解决人类(Homo sapiens)断指和断肢再生提供了理论依据。
[Abstract]:It is the only mammal organ that can be completely regenerated from antler stump every year. It is an ideal model to study the complete regeneration of limb / accessory organ in nature. The results showed that the budding of velvet antler originated from the proliferation and differentiation of periosteal cells in the stalks. Corner stalk periosteum cells can express a variety of embryonic stem cell markers and can be induced to differentiate into a variety of somatic cells in vitro as velvet antler stem cells. Antler stem cells can initiate antler regeneration only when they interact with closely encapsulated hornstalk skin cells. The regeneration process of velvet antler in early stage was similar to that of mouse (Mus musculus) amputated limb wound healing histologically. The difference was the proliferative potential between hornstalk periosteum cells and long bone periosteal cells. It can effectively improve the proliferative potential of the long bone periosteal cells in the amputated limb and approach the hornstalk periosteum cells, which may be able to realize the partial regeneration of the limb of the mammal. In this paper, the research progress of pilose antler tissue regeneration and pilose antler stem cells was reviewed, and the similarities and differences between velvet antler regeneration and salamander (Notophthalmus uiridescens) limb regeneration were compared, and the prospect of pilose antler regeneration model for clinical application was put forward. This paper provides a theoretical basis for solving human (Homo sapiens) amputation and limb regeneration.
【作者单位】： 中国农业科学院特产研究所/特种经济动物分子生物学国家重点实验室;
【基金】：国家高技术研究发展计划(863)项目(No.2011AA100603) 国家自然科学基金项目(No.31170950) 吉林省重点科技攻关项目(No.2015020407NY) 吉林省自然科学基金项目(No.20140101139JC)
【分类号】：S825
本文编号：2331299
[Abstract]:It is the only mammal organ that can be completely regenerated from antler stump every year. It is an ideal model to study the complete regeneration of limb / accessory organ in nature. The results showed that the budding of velvet antler originated from the proliferation and differentiation of periosteal cells in the stalks. Corner stalk periosteum cells can express a variety of embryonic stem cell markers and can be induced to differentiate into a variety of somatic cells in vitro as velvet antler stem cells. Antler stem cells can initiate antler regeneration only when they interact with closely encapsulated hornstalk skin cells. The regeneration process of velvet antler in early stage was similar to that of mouse (Mus musculus) amputated limb wound healing histologically. The difference was the proliferative potential between hornstalk periosteum cells and long bone periosteal cells. It can effectively improve the proliferative potential of the long bone periosteal cells in the amputated limb and approach the hornstalk periosteum cells, which may be able to realize the partial regeneration of the limb of the mammal. In this paper, the research progress of pilose antler tissue regeneration and pilose antler stem cells was reviewed, and the similarities and differences between velvet antler regeneration and salamander (Notophthalmus uiridescens) limb regeneration were compared, and the prospect of pilose antler regeneration model for clinical application was put forward. This paper provides a theoretical basis for solving human (Homo sapiens) amputation and limb regeneration.
【作者单位】： 中国农业科学院特产研究所/特种经济动物分子生物学国家重点实验室;
【基金】：国家高技术研究发展计划(863)项目(No.2011AA100603) 国家自然科学基金项目(No.31170950) 吉林省重点科技攻关项目(No.2015020407NY) 吉林省自然科学基金项目(No.20140101139JC)
【分类号】：S825
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