犬乳腺肿瘤组织病理学观察及腱糖蛋白C表达的检测

发布时间：2018-11-15 20:39

【摘要】：为了探讨腱糖蛋白C(TNC)表达与犬乳腺肿瘤生物学关系,对23例犬乳腺肿瘤临床病例进行病理学观察及分类,然后采用免疫组化SABC方法检测TNC蛋白在23例犬乳腺肿瘤和2例犬正常乳腺组织中的表达情况。结果显示:23例病例中,良性肿瘤有7例,占30.43%;恶性肿瘤有13例,占56.52%;增生病变有3例,占13.05%。在良性肿瘤中良性混合瘤最多,为3例,其余2例为导管内乳头状腺瘤,1例复杂腺瘤及1例纤维腺瘤。恶性肿瘤中,5例未分化癌,3例癌肉瘤,2例筛状癌,2例固体癌,1例纤维肉瘤,1例混合瘤引起的癌。TNC蛋白主要表达于细胞外基质。犬恶性乳腺肿瘤中,TNC蛋白阳性表达率为46.15%(6/13);良性乳腺肿瘤中,其阳性表达率为42.85%(3/7);乳腺增生病变和正常乳腺组织中,未见其表达。研究结果表明,TNC蛋白可以为犬乳腺肿瘤的鉴别诊断提供参考。
[Abstract]:In order to investigate the relationship between the expression of tendonin C (TNC) and the biology of canine breast tumor, 23 cases of canine breast tumor were observed and classified by pathology. Then immunohistochemical SABC method was used to detect the expression of TNC protein in 23 canine breast tumors and 2 canine normal breast tissues. The results showed that there were 7 benign tumors (30.43%), 13 malignant tumors (56.52%) and 3 proliferative lesions (13.05%). Among benign tumors, 3 cases were benign mixed tumors, 2 cases were intraductal papillary adenoma, 1 case was complex adenoma and 1 case was fibroadenoma. Among the malignant tumors, 5 cases were undifferentiated carcinoma, 3 cases were carcinosarcoma, 2 cases were ethmoid carcinoma, 2 cases were solid carcinoma, 1 case was fibrosarcoma, and 1 case was caused by mixed tumor. TNC protein was mainly expressed in extracellular matrix. The positive expression rate of TNC protein was 46.15% (6 / 13) in malignant breast tumors, 42.85% (3 / 7) in benign breast tumors, and no expression was found in proliferative breast lesions and normal breast tissues. The results show that TNC protein can provide reference for differential diagnosis of canine breast tumors.
【作者单位】：浙江省医学科学院;南京农业大学动物医学院;
【分类号】：S858.292

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