白眉长臂猿感染戊型肝炎病毒的病理学观察
发布时间：2019-06-20 13:40
【摘要】：2010年3月8日,北京动物园1只白眉长臂猿突发死亡,通过组织病理学和免疫组织化学等方法对该病死白眉长臂猿死因进行分析。大体剖检观察显示心脏表面可见灰白色病灶,肝脏表面散在大小不一黄白色病灶,肾脏成土黄色,肺脏大面积出血,胃黏膜有散在出血点,肠道水肿,肠系膜淋巴结肿大。病理组织学观察结果显示心肌坏死严重,肺脏严重出血并含有大量炎性细胞浸润,肝脏肝细胞变性坏死并有大量的炎性细胞浸润,肾脏肾小管上皮细胞变性坏死,肾小管管腔中含有黄绿色的小结晶体,肠黏膜水肿。免疫组织化学检测肝脏、肾脏戊型肝炎病毒ORF 2阳性。综合诊断该白眉长臂猿因感染戊型肝炎病毒而导致抵抗力减弱,从而导致肾脏肾小管蛋白凝集发生结晶,引发尿毒症,而后导致心肌坏死,从而导致死亡。
[Abstract]:On March 8, 2010, a white eyebrow gibbon died suddenly in Beijing Zoo. The cause of death of white eyebrow gibbon was analyzed by histopathology and immunohistochemistry. Gross examination showed grayish white lesions on the surface of the heart, yellow and white lesions scattered on the surface of the liver, khaki yellow in the kidney, massive hemorrhage in the lungs, scattered bleeding points in the gastric mucosa, intestinal edema and mesenteric lymph node enlargement. The results of pathological observation showed that myocardial necrosis was serious, lung bleeding was serious and a large number of inflammatory cells infiltrated, liver hepatocytes denatured and necrotic and a large number of inflammatory cells infiltrated, renal tubular epithelial cells denatured and necrotic, renal tubular lumen containing yellow-green nodular crystals and intestinal mucosa edema. The positive rate of hepatitis E virus ORF 2 in liver and kidney was detected by immunohistochemistry. Comprehensive diagnosis of the white eyebrow gibbon caused by hepatitis E virus caused by the weakening of resistance, resulting in renal tubulin aggregation crystallization, leading to uremia, and then lead to myocardial necrosis, resulting in death.
【作者单位】： 中国农业大学动物医学院;北京动物园;
【分类号】：S858.9
本文编号：2503264
[Abstract]:On March 8, 2010, a white eyebrow gibbon died suddenly in Beijing Zoo. The cause of death of white eyebrow gibbon was analyzed by histopathology and immunohistochemistry. Gross examination showed grayish white lesions on the surface of the heart, yellow and white lesions scattered on the surface of the liver, khaki yellow in the kidney, massive hemorrhage in the lungs, scattered bleeding points in the gastric mucosa, intestinal edema and mesenteric lymph node enlargement. The results of pathological observation showed that myocardial necrosis was serious, lung bleeding was serious and a large number of inflammatory cells infiltrated, liver hepatocytes denatured and necrotic and a large number of inflammatory cells infiltrated, renal tubular epithelial cells denatured and necrotic, renal tubular lumen containing yellow-green nodular crystals and intestinal mucosa edema. The positive rate of hepatitis E virus ORF 2 in liver and kidney was detected by immunohistochemistry. Comprehensive diagnosis of the white eyebrow gibbon caused by hepatitis E virus caused by the weakening of resistance, resulting in renal tubulin aggregation crystallization, leading to uremia, and then lead to myocardial necrosis, resulting in death.
【作者单位】： 中国农业大学动物医学院;北京动物园;
【分类号】：S858.9
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