VEGF在雌性哺乳动物生殖过程中作用的研究进展

发布时间：2019-07-21 21:26

【摘要】：血管内皮生长因子(vascular endothelial growth factor,VEGF)是一种具有增加血管通透性、促进细胞分裂增殖以及促进血管形成等多种作用的因子,对生殖过程也有着独特而重要的作用。VEGF的生物功能必须通过与高亲和力的酪氨酸激酶受体结合:其主要受体为VEGFR-1(the fms-like tyrosine kinase,Flt-1)和VEGFR-2(fetal liver kinase-1/kinase insert domain-containing receptor,Flk-1/KDR)。大量的研究发现,在雌性动物生殖过程中,VEGF及其受体在卵泡、黄体、胚胎、胎盘和子宫内膜等组织中均有不同程度的表达。VEGF-受体系统通过自分泌和旁分泌方式发挥作用,参与了卵泡发育、卵母细胞成熟、黄体血管形成、子宫内膜变化、胚胎着床、胎盘血管形成以及胎儿发育等多种重要过程;而VEGF或其受体的基因缺失将导致黄体血管发育紊乱或停滞,胚胎发育异常甚至早期胚胎死亡。此外,近年来的研究发现,VEGF还可以促进卵母细胞的体外成熟和胚胎体外发育。本文综述了VEGF及其受体的结构和生物特性,回顾了其在雌性动物生殖过程中的生理功能,并讨论了其未来的可能研究方向,以期为VEGF及其受体的相关研究提供理论参考。
[Abstract]:Vascular endothelial growth factor (vascular endothelial growth factor,VEGF) is a kind of factor which has many functions, such as increasing vascular permeability, promoting cell division and proliferation, promoting vascular formation and so on. VEGF also plays a unique and important role in the reproductive process. The biological function of VEGF must bind to high affinity tyrosine kinase receptor: its main receptor is VEGFR-1 (the fms-like tyrosine kinase,). Flt-1 and VEGFR-2 (fetal liver kinase-1/kinase insert domain-containing receptor,Flk-1/KDR). A large number of studies have found that VEGF and its receptors are expressed in follicles, corpus, embryos, placenta and uterus to varying degrees in the reproductive process of female animals. VEGF-receptor system plays an important role through autocrine and paracrine, which is involved in many important processes, such as follicular development, oocyte maturation, corpus vascularization, endometrial changes, embryo implantation, placental angiogenesis and fetal development. The deletion of VEGF or its receptor gene will lead to the disorder or stagnation of corpus luteum blood vessels, abnormal embryonic development and even early embryonic death. In addition, recent studies have found that VEGF can also promote oocyte maturation and embryo development in vitro. In this paper, the structure and biological characteristics of VEGF and its receptors are reviewed, their physiological functions in the reproductive process of female animals are reviewed, and their possible research directions in the future are discussed in order to provide theoretical reference for the related research of VEGF and its receptors.
【作者单位】：江苏省农业科学院畜牧研究所;
【基金】：中国博士后科学基金面上项目(No.2013M531298)
【分类号】：S814.1

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