脂肪酸对动物骨骼肌的代谢调控作用

发布时间：2019-07-28 15:16

【摘要】：传统观点认为,脂肪酸的主要作用是给细胞供能。最近研究显示,脂肪酸对细胞的生长发育和代谢都有调控作用。骨骼肌作为脂肪酸代谢的重要场所,是脂肪酸发挥调控作用的主要靶标。棕榈酸与骨骼肌胰岛素抵抗(IR)密切相关;油酸通过过氧化物酶体增殖体活化受体促进脂肪酸的氧化和甘油三酯的合成;亚麻酸可通过促进葡萄糖的利用,缓解骨骼肌的胰岛素抵抗;共轭亚油酸(CLA)通过多条信号通路影响骨骼肌的代谢活动;二十二碳六烯酸(DHA)和花生四烯酸(ARA)能显著改变骨骼肌肌球蛋白重链的基因表达;二十碳五烯酸(EPA)对骨骼肌的糖代谢、线粒体活动和Apelin系统都有一定影响。作者通过对不同脂肪酸对骨骼肌的调控作用进行探讨,试图揭示不同脂肪酸的差异化调控机制,从而为开发脂肪酸产品提供一定的理论依据。
[Abstract]:According to the traditional view, the main function of fatty acids is to supply energy to cells. Recent studies have shown that fatty acids regulate the growth, development and metabolism of cells. Skeletal muscle, as an important place of fatty acid metabolism, is the main target of fatty acid regulation. Palmitic acid is closely related to insulin resistance (IR) in skeletal muscle, oleic acid promotes fatty acid oxidation and synthesis of glycerides through peroxisome proliferator activated receptors, linolenic acid can alleviate insulin resistance in skeletal muscle by promoting glucose utilization, conjugated linoleic acid (CLA) affects metabolic activity of skeletal muscle through multiple signaling pathways. 22 carbohexaenic acid (DHA) and arachidonic acid (ARA) could significantly change the gene expression of myosin heavy chain in skeletal muscle, and eicosapentaenic acid (EPA) had some effects on glucose metabolism, mitochondrial activity and Apelin system in skeletal muscle. By discussing the regulatory effect of different fatty acids on skeletal muscle, the author tries to reveal the differential regulation mechanism of different fatty acids, so as to provide a certain theoretical basis for the development of fatty acid products.
【作者单位】：华南农业大学动物科学学院;
【基金】：国家重点基础研究发展计划(2012CB124701)
【分类号】：S852.2

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