宫颈绒毛管状腺癌38例临床病理分析

发布时间：2018-01-13 10:30

本文关键词：宫颈绒毛管状腺癌38例临床病理分析　出处：《现代妇产科进展》2015年10期 　论文类型：期刊论文

【摘要】：目的:探讨宫颈绒毛管状腺癌(VGA)的临床病理特点及预后影响因素。方法:收集北京协和医院妇产科于1995年1月至2015年1月收治的503例宫颈腺癌的病例资料,其中VGA 38例,分析患者的年龄分布、临床病理特点、预后及其影响因素。结果:VGA患者中位年龄为41.0岁(27~76岁)。最常见的临床症状为接触性出血(68.5%);IA期3例,IB期31例,IIA期2例,IIB期2例;34例患者接受根治性子宫切除术及(或)盆腔淋巴结清扫术,其中1例患者发现淋巴血管间隙受累,1例卵巢转移,1例复发;2例患者放化疗后行全子宫切除术;2例患者行保留生育功能的手术。38例VGA与同期收治的326例宫颈腺癌的临床病理特点进行比较,发现两组的肿瘤分化程度、宫颈肌层浸润深度、淋巴脉管间隙浸润、淋巴结转移、肿瘤复发等因素有统计学差异(P0.05)。结论:VGA的发病年龄较轻,以外生型肿瘤多见,诊断时绝大多数患者处于临床早期,肿瘤分化程度较好,浸润深度较浅,淋巴脉管间隙浸润及淋巴结转移少见,是预后较好的宫颈腺癌型别,行保留生育功能的手术治疗是可行的。
[Abstract]:Objective: to study the VGA of cervical villous tubular adenocarcinoma. Methods: data of 503 cases of cervical adenocarcinoma admitted from January 1995 to January 2015 were collected. The age distribution and clinicopathological characteristics of 38 patients with VGA were analyzed. Results the median age of the patients with VGA was 41.0 years old and 2776 years old. The most common clinical symptom was contact hemorrhage. There were 3 cases of stage IA, 31 cases of stage IIA and 2 cases of stage IIB. 34 patients underwent radical hysterectomy and / or pelvic lymph node dissection. Total hysterectomy was performed in 2 patients after radiotherapy and chemotherapy. The clinicopathological features of 2 cases of VGA and 326 cases of cervical adenocarcinoma were compared. The degree of tumor differentiation and the depth of myometrium infiltration were found in the two groups. There were significant differences in lymphatic vascular space invasion, lymph node metastasis and tumor recurrence (P 0.05). Conclusion the age of VGA is younger and ectogenic tumors are more common. Most of the patients were in the early clinical stage, the tumor differentiation was better, the depth of invasion was shallow, the lymphatic vascular space infiltration and lymph node metastasis were rare, and the prognosis of cervical adenocarcinoma was better. It is feasible to perform surgical treatment to preserve fertility function.
【作者单位】：中国医学科学院北京协和医院妇产科;
【基金】：国家自然科学基金(No:H1621)
【分类号】：R737.33
【正文快照】： Clinical and pathological analysis of patients with villoglandular adenocarcinoma of thecervix:a retrospective study of 38 cases.Liu Pengfei,Guo Peng,Wu Ming,et al.Departmentof Obstetrics and Gynecology,Peking Union Medical College Hospital,Chinese Acade

【参考文献】