小剂量右美托咪定对宫颈癌微创手术患者恶心呕吐影响的研究

发布时间：2018-01-25 23:53

  本文关键词： 小剂量 右美托咪定 宫颈肿瘤 外科手术 微创性 手术后恶心呕吐　出处：《重庆医学》2017年36期 　论文类型：期刊论文

【摘要】：目的探究小剂量右美托咪定对宫颈癌微创手术患者恶心呕吐的影响。方法选取2014年6月至2016年6月海南省中医院收治的122例宫颈癌微创手术患者为研究对象,将患者采用随机数表法分为对照组和观察组,各61例。麻醉诱导前观察组患者经1min静脉注射0.1μg/kg右美托咪定,对照组患者给予等量生理盐水。对比两组患者围术期各项指标、恶心呕吐分级和不良反应发生情况。结果两组患者的麻醉时间、手术时间、睁眼时间、自主呼吸恢复时间、拔除气管导管时间比较,差异无统计学意义(P0.05)。观察组患者术中心率(HR)最低值低于对照组患者,心动过缓发生率高于对照组患者,差异有统计学意义(P0.05)。T2时刻(术后1.0h)观察组患者恶心呕吐分级(PONV)Ⅱ级构成比显著低于对照组T2时刻PONVⅡ级构成比,T4时刻(术后24.0h)观察组患者恶心呕吐发生率显著低于对照组,差异有统计学意义(P0.05)。对照组患者的躁动发生率高于观察组,差异有统计学意义(P0.05)。结论小剂量右美托咪定能够显著缓解宫颈癌微创手术患者术后恶心呕吐,并能够降低躁动发生率,且不会影响麻醉效果,但容易发生心动过缓。
[Abstract]:Objective to investigate the effect of low-dose dexmetomidine on nausea and vomiting in patients with cervical cancer undergoing minimally invasive surgery. Methods 122 patients with cervical cancer undergoing minimally invasive surgery from June 2014 to June 2016 in Hainan Provincial Hospital of traditional Chinese Medicine were selected. Who is the object of study. The patients were randomly divided into control group (n = 61) and observation group (n = 61). Before anesthesia induction, patients in observation group were given 0.1 渭 g / kg dexmetidine intravenously before anesthesia induction. The patients in the control group were given the same amount of normal saline. The perioperative indexes, nausea and vomiting grade and adverse reactions were compared between the two groups. Results the anesthesia time, operation time and eye opening time were compared between the two groups. There was no significant difference in the time of spontaneous respiratory recovery and tracheobronchial extubation (P 0.05). The lowest value of heart rate in the observation group was lower than that in the control group. The incidence of bradycardia was higher than that in control group. The difference was statistically significant (P 0.05). T2 (1.0 h after operation) the nausea and vomiting grade of the patients in the observation group was PONV1). The grade 鈪，

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