乳腺癌术后并发妇科生殖道恶性肿瘤的高危因素分析

发布时间：2018-03-04 04:24

本文选题：乳腺癌　切入点：子宫内膜癌　出处：《首都医科大学学报》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨乳腺癌术后并发妇科恶性肿瘤病人的高危因素。方法对首都医科大学附属北京朝阳医院收治的乳腺癌术后并发妇科恶性肿瘤病人进行随访,按照病例组∶对照组=1∶4的比例选取未并发妇科恶性肿瘤的乳腺癌病人作为对照组,收集病人乳腺癌相关资料、月经生育相关资料、肿瘤家族史等资料,采用SPSS18.0统计软件进行数据统计,单因素分析采用χ2检验,多因素分析采用非条件Logistic回归。结果乳腺癌并发的妇科恶性肿瘤包括子宫内膜癌及卵巢癌。单因素分析显示,初潮年龄(OR=6.5,95%CI:2.37~27.81)、一级亲属肿瘤家族史(OR=3.57,95%CI:1.27~10.06)、乳腺或妇科恶性肿瘤家族史(OR=5.13,95%CI:1.47~17.92)、合并糖尿病(OR=2.12,95%CI:1.32~12.70)是乳腺癌并发妇科恶性肿瘤的高危因素。术后内分泌治疗(OR=0.29,95%CI:0.11~0.78)、术后定期妇科检查(OR=0.33,95%CI:0.12~0.86)降低乳腺癌并发妇科恶性肿瘤的危险。多因素分析显示,乳腺或妇科恶性肿瘤家族史(P=0.003,OR=5.951)、初潮年龄早(P=0.000,OR=9.909)、患有糖尿病(P=0.010,OR=9.842)是乳腺癌并发妇科恶性肿瘤的高危因素,乳腺癌术后定期妇科检查(P=0.037,OR=0.268)是其保护性因素。结论肿瘤家族史尤其是乳腺或妇科恶性肿瘤家族史、初潮年龄早、合并糖尿病是乳腺癌术后发生妇科恶性肿瘤的高危因素,术后定期妇科检查是避免并发妇科恶性肿瘤的保护性因素。
[Abstract]:Objective to investigate the high risk factors of breast cancer complicated with gynecologic malignant tumor after operation. Methods follow up the patients with gynecologic malignancy after breast cancer operation in Beijing Chaoyang Hospital affiliated to Capital Medical University. According to the case group: control group 1: 4 selected breast cancer patients without gynecologic malignancy as control group, collected data related to breast cancer, menstrual birth related data, family history of tumor, etc. SPSS18.0 statistical software was used to analyze the data, 蠂 2 test was used for univariate analysis and non-conditional Logistic regression was used for multivariate analysis. Results the gynecologic malignant tumors complicated by breast cancer, including endometrial carcinoma and ovarian cancer, were analyzed by univariate analysis. The age of menarche is 6.5% 2.37% 27.81%, the family history of first-degree relatives' tumor is 3.5795 CI: 1.2710.06, the family history of breast or gynecological malignant tumor is OR5.13 ~ 95CI: 17.92, and the diabetes mellitus OR2.1295CI1.3212.70) is the high risk factor of breast cancer complicated with gynecologic malignancy. The postoperative endocrine therapy OR0.2995CIT 0.110.78, and the regular gynecological examination after operation, OR0.33C95CI0.12o 0.86) decrease the risk factor of breast cancer complicated with gynecologic malignancy (OR2.1295CI1.321.3212.70). Low risk of breast cancer complicated with gynecologic malignancy. Multivariate analysis showed that, The family history of breast or gynecological malignancy (P0. 003) was 5.951, and the age of menarche was 0. 000, OR9. 909, with diabetes mellitus (P0. 010) and OR9. 842) was a high risk factor for breast cancer complicated with gynecologic malignancy. Conclusion the family history of breast cancer, especially the family history of breast cancer or gynecological malignant tumor, early menarche age and diabetes mellitus are the high risk factors for the occurrence of gynecologic malignant tumor after breast cancer operation. Regular gynecologic examination after operation is a protective factor to avoid complicated gynecologic malignant tumor.
【作者单位】：首都医科大学附属北京朝阳医院妇产科;首都医科大学附属北京朝阳医院乳腺外科;
【分类号】：R73

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