血清胱抑素C对妊娠期高血压疾病孕妇肾功能损害的诊断价值

发布时间：2018-03-10 21:41

本文选题：妊娠期高血压疾病　切入点：胱抑素C　出处：《中国妇产科临床杂志》2015年04期 　论文类型：期刊论文

【摘要】：目的探讨血清胱抑素C(Cys-C)对妊娠期高血压疾病(妊高病)孕妇肾功能损害的临床诊断价值。方法分别采用颗粒增强散射比浊法、酶偶联连续监测法、碱性苦味酸法检测125例妊高病(其中轻度子痫前期51例,重度子痫前期74例)及50例正常孕妇(对照组)血清Cys-C、肌酐(Cre)及尿素氮(BUN)水平。结果妊高病组孕妇Cys-C、BUN及Cre水平明显高于对照组(P0.05),轻度子痫前期组Cys-C水平明显高于对照组(P0.05),重度子痫前期组Cys-C阳性率明显高于轻度子痫前期组(P0.05)。轻度和重度子痫前期组Cys-C阳性率显著高于BUN和Cre(P0.05)。Cys-C诊断妊高病肾功能损害的灵敏度为93.6%,特异度为92.0%,阳性预测值为96.7%。结论血清Cys-C检测是早期发现妊高病孕妇肾功能损害的一项重要指标。
[Abstract]:Objective to investigate the value of serum cystatin Cys-Cin in the diagnosis of renal dysfunction in pregnant women with pregnancy-induced hypertension (PIH). Basic picric acid method was used to detect 125 cases of PIH (51 cases of mild preeclampsia). The serum levels of Cys-Cn, creatinine creatinine (creatinine) and bun (bun) in pregnant women with PIH were significantly higher than those in the control group (P 0.05), and the levels of Cys-C in mild preeclampsia group were significantly higher than those in the control group. The positive rate of Cys-C in severe preeclampsia group was significantly higher than that in mild preeclampsia group, and the positive rate of Cys-C in mild and severe preeclampsia group was significantly higher than that in BUN and Cre(P0.05).Cys-C group. Conclusion Detection of serum Cys-C is an important index for early detection of renal dysfunction in pregnant women with PIH.
【作者单位】：深圳市宝安区石岩人民医院妇产科;
【分类号】：R714.246

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