晚发型子痫前期患者血清、尿液2-甲氧雌二醇水平及胎盘COMT蛋白表达及意义

发布时间：2018-03-19 01:34

本文选题：晚发型子痫前期　切入点：儿茶酚胺氧位甲基转移酶　出处：《山东医药》2015年32期 　论文类型：期刊论文

【摘要】：目的探讨2-甲氧雌二醇(2-ME)、儿茶酚胺氧位甲基转移酶(COMT)蛋白在晚发型子痫前期(PE)发病中的作用。方法选取孕周34周的晚发型PE患者25例(观察组),同期正常单胎妊娠孕妇35例(对照组)。采用全自动酶标仪检测血清及尿液2-ME水平,Western blotting法检测胎盘组织COMT蛋白相对表达量。结果观察组血清、尿液2-ME分别为(595.3±21.8)、(407.8±16.3)pg/m L,对照组分别为(407.8±23.9)、(298.4±18.1)pg/m L;两组比较,P均0.05。观察组胎盘COMT蛋白相对表达量为1.48±0.66,对照组为1.39±0.58;两组比较,P0.05。结论晚发型PE患者血清、尿液2-ME水平升高,胎盘COMT蛋白表达无明显变化;2-ME可能是其发病过程中的一种代偿性保护因子,而COMT蛋白可能与晚发型PE的发生关系不大。
[Abstract]:Objective to investigate the role of 2-MEM, COMT-protein in the pathogenesis of late onset preeclampsia (PEP). Methods 25 patients with late onset PE (gestational age 34 weeks) were selected. In 35 pregnant women (control group), the relative expression of COMT protein in placenta was detected by using automatic enzyme labeling instrument and 2-ME level in urine and the relative expression of COMT protein in placenta was detected by Western blotting method. Urine 2-ME was 407.8 卤16.3g / mL in urine and 407.8 卤23.9g / mL in control group, respectively. The relative expression of COMT protein in placenta of observation group was 1.48 卤0.66 and that of control group was 1.39 卤0.58.Conclusion the level of urine 2-ME in patients with late onset PE was higher than that in control group, and the relative expression of COMT protein in placenta of observation group was 1.48 卤0.66, and that of control group was 1.39 卤0.58.Conclusion the level of urine 2-ME in patients with late onset PE was higher than that in control group. The expression of COMT protein in placenta may be a compensatory protective factor, while the expression of COMT protein may not be related to the occurrence of late type PE.
【作者单位】：咸宁市中心医院同济咸宁医院;武汉大学中南医院;
【分类号】：R714.244

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