CIP2A及c-Myc在宫颈癌组织中的表达及相关性分析

发布时间：2018-03-23 11:31

本文选题：CIPA　切入点：c-Myc　出处：《重庆医学》2015年08期

【摘要】：目的检测蛋白磷酸酶2A的癌性抑制因子(CIP2A)和c-Myc蛋白在宫颈癌组织中的表达水平并分析二者表达的相关性。方法运用免疫组织化学染色技术检测CIP2A和c-Myc蛋白在72例宫颈癌和12例正常宫颈组织中的表达水平,分析CIP2A和c-Myc与宫颈临床病理特征的相关性以及二者表达的相关性。结果 CIP2A和c-Myc蛋白在宫颈癌组织中的阳性率分别为52.8%(38/72)和56.9%(41/72),而二者在正常宫颈组织中的阳性率分别为8.3%(1/12)和25.0%(3/12),差异有统计学意义(χ2=8.169,P=0.004;χ2=4.208,P=0.040)。CIP2A和c-Myc蛋白表达与肿瘤组织病理分化和临床分期显著相关(P0.05),而与年龄、淋巴结转移和肿瘤病理类型无明显相关性。Pearson相关分析结果显示宫颈癌组织中CIP2A与c-Myc蛋白表达呈显著正相关(r=0.673,P=0.001)。结论宫颈癌组织中CIP2A高表达与恶性临床病理特征密切相关,并与c-Myc蛋白表达呈显著正相关。
[Abstract]:Objective to detect the expression of CIP2A and c-Myc in cervical carcinoma and to analyze the correlation between them. Methods Immunohistochemical staining was used to detect the expression of CIP2A and c-Myc in 72 cases of cervical cancer. Expression levels in cervical cancer and 12 normal cervical tissues, Results the positive rates of CIP2A and c-Myc protein in cervical cancer tissues were 52.8% 38 / 72 and 56.9% / 72 respectively. The positive rate of CIP2A and c-Myc protein in normal cervix tissues was higher than that in normal cervix tissues. The difference was statistically significant (蠂 ~ (2 / 2) 8.169 P ~ (0.004); 蠂 ~ (2 / 2) 4.208). The expression of CIP2A and c-Myc protein were significantly correlated with the pathological differentiation and clinical stage of the tumor (P _ (0.05)), but with age, the difference was significant (P _ (0.05), P _ (0.05), P _ (0.05), P _ (0.05), P _ (0.05), P _ (0.05), P _ (0.05)). There was no significant correlation between lymph node metastasis and pathological type of tumor. Pearson correlation analysis showed that there was a significant positive correlation between the expression of CIP2A and c-Myc protein in cervical carcinoma. Conclusion the high expression of CIP2A in cervical carcinoma is closely related to the clinicopathological features of cervical cancer. There was a significant positive correlation with the expression of c-Myc protein.
【作者单位】：四川省成都市妇女儿童中心医院产科;四川省抗生素研究所;
【分类号】：R737.33

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