孕期携带HBV对母婴结局的影响

发布时间：2018-04-10 00:30

本文选题：HBV　切入点：孕产妇　出处：《中国妇产科临床杂志》2015年03期

【摘要】：目的研究孕妇携带乙型肝炎病毒(HBV)对母婴结局的影响。方法选取2011年1月至2013年12月在南方医科大学中山市博爱医院产检及分娩的乙肝表面抗原(HBsAg)阳性的孕产妇124例为研究组,选取同期产检及分娩的乙肝表面抗原(HBsAg)阴性的健康孕产妇124例为对照组,比较两组不良妊娠结局的发生率。结果 1研究组中孕产妇发生妊娠期高血压疾病、妊娠期糖尿病、妊娠期肝内胆汁淤积症、肝功能损害及产后出血的概率均明显高于对照组,差异有统计学意义(P均0.05);2研究组中发生胎儿窘迫、新生儿小于胎龄儿、新生儿肺炎、新生儿高胆红素血症的概率均明显高于对照组,差异均有统计学意义(P均0.05);3研究组中单阳组的母儿并发症与对照组比较差异无统计学意义(P均0.05);4研究组中双阳组母儿并发症明显高于单阳组,差异均有统计学意义(P均0.05)。结论孕期携带HBV可明显增加孕妇妊娠期及分娩期并发症的发生率,同时增加胎儿窘迫、新生儿肺炎及新生儿高胆红素血症的发生率,对母婴影响较大,临床上要引起重视。
[Abstract]:Objective to study the effect of hepatitis B virus (HBV) on maternal and infant outcomes in pregnant women.Methods from January 2011 to December 2013, 124 pregnant women who were positive for HBsAg in birth and delivery in Boai Hospital, Zhongshan City, Southern Medical University, were selected as the study group.124 healthy pregnant women with HBsAg negative in the same period of labor and delivery were selected as control group. The incidence of adverse pregnancy outcome was compared between the two groups.Results 1the probability of hypertensive disorder complicating pregnancy, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, liver function damage and postpartum hemorrhage in the study group were significantly higher than those in the control group.The difference was statistically significant (P < 0.05). The probability of fetal distress, neonatal pneumonia and neonatal hyperbilirubinemia in the study group was significantly higher than that in the control group, and the incidence of neonatal fetal distress, neonatal pneumonia and neonatal hyperbilirubinemia were significantly higher than those in the control group.There was no significant difference in maternal and fetal complications between single positive group and control group (P 0.05). The maternal and infant complications in double positive group were significantly higher than those in single positive group, and the difference was statistically significant (P 0.05).Conclusion carrying HBV during pregnancy can significantly increase the incidence of complications during pregnancy and delivery, and increase the incidence of fetal distress, neonatal pneumonia and neonatal hyperbilirubinemia.
【作者单位】：南方医科大学中山市博爱医院妇产科;
【分类号】：R714.251

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