VEGF-C、VEGF-D mRNA及D2-40在宫颈癌中表达的临床意义

发布时间：2018-04-21 22:11

本文选题：血管内皮生长因子-C + 血管内皮生长因子-D　；参考：《中国妇产科临床杂志》2015年01期

【摘要】：目的检测宫颈癌组织中VEGF-C、VEGF-D mRNA及D2-40的表达水平。方法采用免疫组化方法、RT-PCR检测正常宫颈、宫颈上皮内瘤变及宫颈癌中VEGF-C、VEGF-D mRNA及D2-40的表达。结果 VEGF-C、VEGF-D mRNA及D2-40在正常宫颈组织、宫颈高级别上皮内瘤变组织及宫颈癌中阳性表达率呈递增关系;VEGF-C、VEGF-D mRNA及D2-40的表达与宫颈癌的临床分期、组织学分级及淋巴转移明显相关,而与年龄及病理学分类无关。VEGF-C与VEGF-D阳性表达不完全一致,两者合测增加阳性表达率。结论 VEGF-C、VEGF-D mRNA及D2-40在宫颈癌组织中高表达,在不同临床分期及组织学分级中的表达水平不同,与宫颈癌淋巴转移有关。
[Abstract]:Objective to detect the expression of VEGF-D mRNA and D 2-40 in cervical carcinoma. Methods the expression of VEGF-Con VEGF-D mRNA and D2-40 in normal cervix, cervical intraepithelial neoplasia and cervical carcinoma were detected by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). Results the positive expression rates of VEGF-D mRNA and D2-40 in normal cervical tissues, cervical high-grade intraepithelial neoplasia and cervical carcinoma were increased. The expression of VEGF-CnVEGF-D mRNA and D2-40 were significantly correlated with the clinical stage, histological grade and lymphatic metastasis of cervical carcinoma. The positive expression of VEGF-C and VEGF-D was not consistent with age and pathological classification. Conclusion VEGF-D mRNA and D2-40 are highly expressed in cervical carcinoma, and the expression levels of VEGF-D mRNA and D2-40 are different in different clinical stages and histological grades, which are related to lymphatic metastasis of cervical carcinoma.
【作者单位】：江苏省南通市第一人民医院妇产科;江苏省南通市第一人民医院检验科;江苏省南通市第一人民医院病理科;
【基金】：江苏省南通市卫生局青年医学人才科研基金(WQ2014024)
【分类号】：R737.33

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