辅助生殖技术对子代儿童患恶性肿瘤风险的Meta分析

发布时间：2018-04-21 22:24

本文选题：生殖技术 + 辅助　；参考：《重庆医学》2015年18期

【摘要】：目的评价辅助生殖技术(ART)对子代儿童恶性肿瘤发生率的影响。方法通过计算机检索EBSCO全文数据库、Pubmed、德国Springer期刊数据库、Cochrane Libarary、中国学术期刊网络出版总库期(CNKI)、万方和维普中文期刊全文数据库等,并辅助其他检索方式,纳入ART术后妊娠和自然妊娠的儿童健康状况的队列研究,使用RevMan5.0软件进行Meta分析。结果研究共纳入符合标准文献16篇,共89 894例ART出生子代。Meta分析结果显示,ART与非ART出生子代恶性肿瘤发生率之间差异无统计学意义(OR=1.85,P0.05)。结论 ART子代罹患恶性肿瘤的概率与非ART基本一致,但其远期的潜在风险尚未明确。
[Abstract]:Objective to evaluate the effect of assisted reproductive technique (art) on the incidence of malignant tumor in children. Methods EBSCO full-text databases were searched by computer, such as EBSCO full-text database, Springer journal database in Germany, Chinese academic journals online publishing database, Wanfang and Weipu full-text databases, and other retrieval methods. A cohort study was conducted on the health status of children with pregnancy after ART and natural pregnancy, and Meta analysis was performed with RevMan5.0 software. Results A total of 16 articles were included in the study. A total of 89 894 cases of ART were born. Meta-analysis showed that there was no significant difference in the incidence of malignant tumors between ART and non ART offspring (P 0. 05). Conclusion the probability of malignant tumor in ART offspring is consistent with that of non-ART, but the long-term potential risk is not clear.
【作者单位】：重庆市中医院脑病科;重庆医科大学附属儿童医院新生儿二病房;
【基金】：国家临床重点专科建设项目(国卫办医[2013]544号)
【分类号】：R714.8

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