小剂量阿司匹林对于重度宫腔粘连电切术后子宫内膜的影响

发布时间：2018-05-01 14:28

本文选题：阿司匹林 + 子宫内膜　；参考：《重庆医学》2015年28期

【摘要】：目的探讨小剂量阿司匹林对于重度宫腔粘连电切术后子宫内膜的影响。方法采用前瞻性随机双盲的方法,将该院确诊为重度宫腔粘连并实施宫腔粘连电切术+宫腔球囊置入术后的患者80例随机分为A、B、C、D 4组,每组20例。A组:补佳乐3mg,3次/日,连续1个月;B组:补佳乐3mg,3次/日+阿司匹林50mg,1次/日,连续1个月;C组:补佳乐3mg,3次/日+阿司匹林75mg,1次/日,连续1个月;D组:补佳乐3mg,3次/日+阿司匹林100mg,1次/日,连续1个月。观察4组患者排卵日子宫内膜厚度、子宫内膜类型、子宫动脉血流阻力指数(RI),子宫动脉搏动指数(PI),记录患者月经恢复情况,术后1个月再次行宫腔镜检查宫腔形状疗效评定。结果 (1)B、C、D 3组患者排卵日子宫内膜厚度,A型内膜所占比例均高于A组,差异有统计学意义(P0.05),RI,PI明显低于A组,差异有统计学意义(P0.05);(2)B、C、D组月经量恢复满意,与A组比较差异有统计学意义(P0.05),但B、C、D组之间差异无统计学意义(P0.05);(3)术后1个月宫腔镜下检查B、C、D组宫腔形状恢复满意,与A组比较差异有统计学意义(P0.05),但B、C、D组之间差异无统计学意义(P0.05)。结论小剂量阿司匹林联合补佳乐可以明显改善宫腔粘连电切术后子宫内膜的发育和恢复。
[Abstract]:Objective to investigate the effect of low-dose aspirin on endometrium after electroresection of severe intrauterine adhesions. Methods 80 patients diagnosed as severe intrauterine adhesions in our hospital were randomly divided into 4 groups: group A (n = 20), and group A (n = 20): Bujialue 3 mg / d, 3 times a day, after balloon implantation of intrauterine adhesions and adhesions were performed in this hospital, and 80 patients were randomly divided into four groups: group A (n = 20), and group A (n = 20). Group B: Bu Jia Le 3 mg / d aspirin 50 mg / d, group C 1 time of aspirin 75 mg / d for 1 month, group D 1 month: bujiale 3 mg / d aspirin 100 mg / day, group C: aspirin 75 mg / d for 1 month, group D: aspirin 100 mg / d for 1 month, group D: 3 mg / d aspirin / day for 1 month, group C: aspirin 75 mg / d for 3 times a day, group D: 3 times a day for 1 month, group D: aspirin 100 mg / day. For one month in a row. The endometrial thickness, endometrial type, uterine artery resistance index (RI) and uterine artery pulsatile index (Pi) were observed on the day of ovulation in the four groups. The menstrual recovery was recorded. The uterine cavity shape was evaluated by hysteroscopy one month after operation. Results the proportion of endometrial thickness and type A endometrium on ovulation day in group D 3 was significantly higher than that in group A, and the Pi of RIN in group A was significantly lower than that in group A, and the difference was statistically significant. There was a significant difference between group A and group A (P 0.05), but there was no significant difference between group B and C (P 0.05). There was significant difference between group A and group A (P 0.05), but there was no significant difference between group D and group B (P 0.05). Conclusion small dose aspirin combined with Bujialao can significantly improve the development and recovery of endometrium after electroresection of intrauterine adhesions.
【作者单位】：重庆市妇幼保健院妇科;
【基金】：重庆市卫生局科研项目(20142099)
【分类号】：R713.4

【参考文献】