Stathmin-1、P27及ki-67在宫颈上皮内瘤变的表达与残留、复发相关性的研究

发布时间：2018-05-21 06:54

本文选题：宫颈上皮内瘤变 + stathmin-　；参考：《中国妇产科临床杂志》2015年01期

【摘要】：目的研究stathmin-1(STMN-1)、P27及ki-67在宫颈上皮内瘤变(CIN)中的表达,探讨其与高级别CIN残留/复发的关系。方法对2010年1月至2013年6月因CIN2~CIN3行宫颈锥形切除患者进行随访,将残留/复发病例36例设为实验组,随机抽取未复发病例40例作为对照组。采用免疫组化法检测两组病例首次宫颈锥切组织中stathmin-1、P27及ki-67的表达。结果 STMN-1实验组30例(83.3%)阳性,对照组16例(40%)阳性,差异有统计学意义(P0.05)。P27实验组27例(75%)阳性,且表达于胞浆,对照组19例(47.5%)阳性,多表达于胞浆,部分核浆均有表达,差异有统计学意义(P0.05)。ki-67实验组35例(97.2%)阳性,对照组35例(87.5%)阳性,差异无统计学意义(P0.05);其在CIN 2中阳性表达率为78.5%,在CIN3中100%表达,差异有统计学意义(P0.05)。结论 STMN-1与P27高表达与高级别宫颈CIN残留、复发有关,对高级别宫颈上皮内瘤变残留、复发有一定的预测价值。ki-67与宫颈病变组织学级别有关,但与疾病残留、复发无关。
[Abstract]:Objective to study the expression of stathmin-1stMN-1p27 and ki-67 in cervical intraepithelial neoplasia (cin), and to explore the relationship between stathmin-1n and high grade CIN residues / recurrence. Methods from January 2010 to June 2013, 36 patients with cervical conical resection due to CIN2~CIN3 were followed up. 36 cases of residual / recurrent cases were divided into experimental group and 40 cases of non-recurrent cases were randomly selected as control group. Immunohistochemical method was used to detect the expression of stathmin-1 P27 and ki-67 in the first cervical conization. Results 30 cases of STMN-1 group were positive, and 16 cases of control group were positive. The difference was statistically significant (P 0.05). P27 group (n = 27) was positive and expressed in cytoplasm, and 19 cases in control group (n = 19) were positive, most of them were positive in cytoplasm, and some of them were expressed in nuclear cytoplasm. The difference was statistically significant in the experimental group (35 cases) and the control group (35 cases). There was no significant difference (P 0.05), but the positive rate in CIN 2 was 78.5%, and in CIN3, 100% (P 0.05%), the difference was statistically significant (P 0.05). Conclusion the high expression of STMN-1 and P27 is related to high grade CIN residue and recurrence of cervical intraepithelial neoplasms. The recurrence of high grade cervical intraepithelial neoplasia is related to histological grade of cervical lesions, but it is not related to residual disease and recurrence.
【作者单位】：青岛大学医学院附属青岛市海慈医疗集团妇科;青岛大学附属医院妇科;
【基金】：山东省青岛市科技局科技支撑计划(13-1-4-118-jch)
【分类号】：R737.33

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