子宫内膜癌和卵巢癌患者血清唾液酸水平检测及其临床价值评估

发布时间：2018-06-16 04:46

本文选题：唾液酸 + 糖类抗原　；参考：《国际检验医学杂志》2017年03期

【摘要】：目的评估血清唾液酸(SA)对子宫内膜癌和卵巢癌的辅助诊断价值。方法利用酶法和电化学发光法分别检测47例子宫内膜癌、30例子宫良性疾病,117例卵巢癌,83例卵巢良性肿瘤患者及60例健康对照者血清SA、糖类抗原125(CA125)和人附睾蛋白4(HE4)水平,以CA125、HE4作为对照指标评估SA诊断子宫内膜癌和卵巢癌的价值。结果早、晚期子宫内膜癌组和卵巢癌患者血清SA水平均明显高于健康组和子宫良性疾病组,差异有统计学意义(P0.05)。与血清CA125指标比较,无论以健康组还是子宫良性疾病组为对照,子宫内膜癌组患者血清SA受试者操作特性曲线下面积(ROC-AUC)比较差异无统计学意义(P0.05);卵巢癌组患者血清SA的ROC-AUC当以健康组为对照时,SA的ROC-AUC低于CA125,以卵巢良性疾病组为对照时则比较差异无统计学意义(P0.05)。在约登指数最大点处,以健康组作为对照时,SA对子宫内膜癌诊断的特异度明显高于CA125,差异有统计学意义(P0.05)。以卵巢良性疾病组为对照时,SA对卵巢癌诊断的敏感度和特异度与CA125和HE4比较,差异无统计学意义(P0.05)。结论 SA对子宫内膜癌和卵巢癌均有较高的敏感度和特异度,适用于两大妇科肿瘤的筛查。
[Abstract]:Objective to evaluate the value of serum sialic acid (SA) in the diagnosis of endometrial and ovarian cancer. Methods 47 cases of endometrial carcinoma, 30 cases of benign uterine diseases, 117 cases of ovarian cancer, 83 cases of ovarian benign tumors and 60 healthy controls were evaluated by enzyme and electrochemiluminescence. The serum SA, CA125 and epididymal protein 4 (H) were measured in 60 cases of benign ovarian cancer and 60 healthy controls. E4) level, using CA125, HE4 as a control index to evaluate the value of SA in the diagnosis of endometrial and ovarian cancer. Results early, late endometrial and ovarian cancer patients were significantly higher in serum SA levels than in the healthy and benign groups of uterus (P0.05). Compared with the serum CA125 index, the level of serum CA125 was better than the healthy group or the uterus. There was no significant difference in the area (ROC-AUC) of the serum SA in the patients with endometrial cancer group (P0.05). The ROC-AUC of the serum SA in the ovarian cancer group was lower than that of the SA in the healthy group as the control group, and the difference was not statistically significant (P0.0) when the ovarian benign disease group was compared with the control group (P0.0). 5) the specificity of SA for endometrial carcinoma was significantly higher than that of CA125 at the maximum point of the health index. The difference was statistically significant (P0.05) in the diagnosis of endometrial carcinoma (P0.05). The sensitivity and specificity of SA for the diagnosis of ovarian cancer were not statistically significant compared with CA125 and HE4 (P0.05). Conclusion SA against the uterus. Endometrial cancer and ovarian cancer have high sensitivity and specificity, and are suitable for screening two major gynecological tumors.
【作者单位】：青岛大学附属医院检验科/山东省医药卫生重点实验室;
【分类号】：R737.3;R730.43

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