两种剂量米非司酮对围绝经期子宫肌瘤患者肌瘤体积的影响

发布时间：2018-06-16 11:30

本文选题：子宫肌瘤体积 + 围绝经期　；参考：《河南医学高等专科学校学报》2016年06期

【摘要】：目的观察低剂量米非司酮对围绝经期子宫肌瘤患者肌瘤体积及预后的影响。方法选择2013年10月—2015年4月来该院就诊的80例围绝经期子宫肌瘤患者为观察对象,随机分为米非司酮1组和米非司酮2组,每组40例。米非司酮1组给予米非司酮12.5 mg/次,1次/日,晚饭前口服;米非司酮2组给予口服米非司酮25mg/次,1次/日,晚饭前口服。两组均连续治疗半年。观察两组治疗效果及肌瘤体积变化情况。结果米非司酮1组治疗总有效率和不良反应发生率分别为95.0%和17.5%,明显低于米非司酮2组(85.0%、37.5%),差异具有统计学意义(P0.05)。米非司酮1组治疗后子宫体积和子宫肌瘤体积分别为(187.54±15.63)cm3和(38.51±6.38)cm3,与米非司酮2组治疗后比较,差异无统计学意义(P0.05)。结论低剂量米非司酮治疗围绝经期子宫肌瘤疗效满意,可显著降低肌瘤体积,且无严重药物不良反应,安全性高,预后较好。
[Abstract]:Objective To observe the effect of low dose mifepristone on the volume and prognosis of myoma in perimenopausal uterine myoma. Methods 80 cases of perimenopausal uterine myoma in the hospital from October 2013 to April 2015 were selected and randomly divided into 1 groups of mifepristone and 2 groups of mifepristone, 40 cases in each group. Mifepristone was given to the 1 group of mifepristone 1. 2.5 mg/ times, 1 times per day, oral administration before supper; the 2 group of mifepristone was given oral mifepristone 25mg/ times, 1 times / day, and oral administration before supper. The two groups were treated for six months continuously. The treatment effect of two groups and the changes of myoma volume were observed. Results the total effective rate and adverse reaction rate of mifepristone group 1 were 95% and 17.5%, respectively, lower than micifera. The difference between the 2 groups (85%, 37.5%) was statistically significant (P0.05). The volume and volume of uterine fibroids were (187.54 + 15.63) cm3 and (38.51 + 6.38) cm3 respectively after the treatment of mifepristone group 1. The difference was not statistically significant after the treatment of mifepristone 2 group (P0.05). Conclusion low dose mifepristone was effective in the treatment of perimenopausal uterine myoma. It can significantly reduce the volume of myoma and has no serious adverse drug reactions. It has high safety and good prognosis.
【作者单位】：长葛卫生职业中等专业学校附属医院妇产科;
【分类号】：R737.33

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