知柏更安汤联合克龄蒙治疗阴虚火旺型绝经综合征的临床研究

发布时间：2018-06-21 05:12

本文选题：知柏更安汤 + 克龄蒙　；参考：《山东中医药大学》2014年硕士论文

【摘要】：目的：比较中药知柏更安汤联合克龄蒙及单用克龄蒙治疗阴虚火旺型绝经综合征的作用差别，确立阴虚火旺型绝经综合征中西医结合治疗方案。并且通过观察中药知柏更安汤联合克龄蒙治疗阴虚火旺型绝经综合征的临床疗效，探讨其作用机理，为推广应用提供理论依据。方法：筛选阴虚火旺型绝经综合征患者60例，随机分为治疗组30例：服用知柏更安汤的同时，服用克龄蒙，共治疗3个疗程。对照组30例：服用克龄蒙治疗3个疗程。观察两组用药3个疗程后的改良Kupperman评分，中医证候评分，和血清促卵泡激素(FSH)，黄体生成素(LH)，雌二醇(E2)的变化。结果：1.临床疗效比较：治疗后治疗组总有效率为93.33%，对照组总有效率为70.00%，两组组间比较，X2＝4.007，P＝0.045＜0.05，差异有统计学意义，，说明治疗组优于对照组。2.中医证候疗效比较：治疗后治疗组总有效率为96.67%，对照组总有效率为73.33%，两组组间比较，X2＝4.242，P＝0.039＜0.05，差异有统计学意义，说明治疗组优于对照组。3.治疗组与对照组组内比较，改良Kupperman评分、中医证候评分治疗后较治疗前均降低，差异均有高度统计学意义(P＜0.01)；组间比较,差异均有高度统计学意义(P＜0.01)。4.治疗前,两组患者E2、FSH、LH比较，差异均无统计学意义(P＞0.05)，具有可比性。治疗后，两组E2较治疗前升高，差异有高度统计学意义(P＜0.01)。FSH、LH较治疗前降低，差异均有高度统计学意义(P＜0.01)。两组组间比较，E2差异有统计学意义(P＜0.05)，FSH、LH差异均无统计学意义(P＞0.05)。结论：在用中药知柏更安汤治疗的基础上联合克龄蒙治疗阴虚火旺型绝经综合征具有更好的临床疗效，能够明显改善中医证候，其作用机制与其从整体上调整神经内分泌紊乱有关，为本病的中西医结合治疗及进一步研究提供了一定的客观依据，值得在临床中推广应用。
[Abstract]:Objective: to compare the effect of Zhibaiganan decoction combined with Kelingmeng and Kelingmeng alone in the treatment of Yin-deficiency Huowang menopausal syndrome, and to establish the integrated treatment scheme of traditional Chinese and western medicine for Yin-deficiency Huo-wang menopausal syndrome. And by observing the clinical effect of Zhibaiganan decoction combined with Kelingmeng in treating menopausal syndrome with yin deficiency and fire, the mechanism of its action was discussed, and the theoretical basis for popularization and application was provided. Methods: a total of 60 cases of Yin-deficiency and Huo-wang type menopause syndrome were selected and randomly divided into treatment group (n = 30): taking Zhibengan decoction and taking Ke Ling Meng for 3 courses of treatment. The control group (n = 30) was treated with Kelingmen for 3 courses. The changes of modified Kupperman score, TCM syndrome score and serum follicle stimulating hormone (FSH), luteinizing hormone (LHN) and estradiol (E _ 2) were observed in the two groups after 3 courses of treatment. The result is 1: 1. Comparison of clinical efficacy: the total effective rate of the treatment group was 93.33, the total effective rate of the control group was 70.005, and the comparison between the two groups was X24.007P0. 045 < 0. 05, the difference was statistically significant, indicating that the treatment group was superior to the control group. 2. Comparison of TCM syndromes efficacy: after treatment, the total effective rate of the treatment group was 96.677.The total effective rate of the control group was 73.33.The difference between the two groups was statistically significant, indicating that the treatment group was superior to the control group (.3). Compared with the control group, the modified Kupperman score and TCM syndrome score decreased after treatment (P < 0.01), and there were significant differences between the two groups (P < 0.01). Before treatment, there was no significant difference between the two groups (P > 0.05). After treatment, E _ 2 in the two groups was higher than that before treatment, and the difference was statistically significant (P < 0.01). FSHLH was lower than that before treatment, and the difference was statistically significant (P < 0.01). There was no significant difference in E _ 2 between the two groups (P < 0.05) and there was no significant difference in FSH LH between the two groups (P > 0.05). Conclusion: on the basis of traditional Chinese medicine Zhibogenan decoction combined with Kelingmeng in the treatment of Yin-deficiency and Huo-Wang type menopausal syndrome, it has better clinical effect and can obviously improve TCM syndromes. The mechanism is related to the adjustment of neuroendocrine disorder, which provides a certain objective basis for the treatment and further study of this disease, and is worth popularizing in clinic.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R711.75

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