微量子宫内膜活检在子宫内膜癌及癌前病变筛查中的应用价值
发布时间：2018-07-14 16:16
【摘要】：目的评估微量子宫内膜活检标本在子宫内膜癌及癌前病变筛查中的应用价值。方法收集北京大学人民医院及北京市大兴区人民医院子宫内膜活检标本589例,分别采用环状微量子宫内膜取样器以及分段诊刮获取子宫内膜组织,进行病理学诊断,观察微量子宫内膜活检取样合格率,及其与子宫内膜厚度、年龄的关系,并分析微量子宫内膜活检在子宫内膜癌及癌前病变筛查中的敏感度及特异性,筛选其相对适用人群。结果两家医院微量子宫内膜活检取样合格率为71.5%(421/589),子宫内膜较厚(≥5 mm)、年龄较小(50岁)的患者更易获得合格的微量子宫内膜活检标本;在微量子宫内膜活检取样合格的标本中检出子宫内膜癌及癌前病变55例,与分段诊刮比较其敏感性为75.3%(55/73),特异性为99.4%(332/334)。结论微量子宫内膜活检标本合格率仍有待提高,相对适用于年轻及子宫内膜较厚的人群,但在取样合格的标本中,其筛查子宫内膜癌及癌前病变特异度较高,表明采用微量子宫内膜活检可以作为高危人群子宫内膜癌筛查的备选方法。
[Abstract]:Objective to evaluate the value of micro endometrial biopsy specimens in screening of endometrial carcinoma and precancerous lesions. Methods 589 specimens of endometrium biopsy specimens from Peking University People's Hospital and hospital were collected, and the endometrium tissue was obtained by circular micro endometrium sampler and segmental curettage. The qualification rate of microendometrial biopsy samples, the relationship with endometrial thickness and age, and the sensitivity and specificity of microendometrial biopsy in endometrial cancer and precancerous lesions were analyzed and the relative population was screened by microendometrial biopsy. The results were 71.5% (42). 1/589), the endometrium was thicker (more than 5 mm), and the younger (50 years old) patients were more likely to obtain qualified micro endometrium biopsy specimens; 55 cases of endometrial cancer and precancerous lesions were detected in qualified specimens of micro endometrial biopsy samples. Compared with the segmental curettage, the sensitivity was 75.3% (55/73) and the specificity was 99.4% (332/334). The qualified rate of endometrium biopsy remains to be improved, which is relatively suitable for young people and thicker endometrium, but the specificity of screening for endometrial cancer and precancerous lesions is high in qualified samples, indicating that micro endometrial biopsy can be used as a alternative for screening endometrium cancer in high-risk groups.
【作者单位】： 首都医科大学大兴教学医院病理科;首都医科大学大兴教学医院妇产科;北京大学人民医院妇产科;北京大学人民医院病理科;
【基金】：首都卫生发展科研专项项目(2014-3-7122)
【分类号】：R737.33
[Abstract]:Objective to evaluate the value of micro endometrial biopsy specimens in screening of endometrial carcinoma and precancerous lesions. Methods 589 specimens of endometrium biopsy specimens from Peking University People's Hospital and hospital were collected, and the endometrium tissue was obtained by circular micro endometrium sampler and segmental curettage. The qualification rate of microendometrial biopsy samples, the relationship with endometrial thickness and age, and the sensitivity and specificity of microendometrial biopsy in endometrial cancer and precancerous lesions were analyzed and the relative population was screened by microendometrial biopsy. The results were 71.5% (42). 1/589), the endometrium was thicker (more than 5 mm), and the younger (50 years old) patients were more likely to obtain qualified micro endometrium biopsy specimens; 55 cases of endometrial cancer and precancerous lesions were detected in qualified specimens of micro endometrial biopsy samples. Compared with the segmental curettage, the sensitivity was 75.3% (55/73) and the specificity was 99.4% (332/334). The qualified rate of endometrium biopsy remains to be improved, which is relatively suitable for young people and thicker endometrium, but the specificity of screening for endometrial cancer and precancerous lesions is high in qualified samples, indicating that micro endometrial biopsy can be used as a alternative for screening endometrium cancer in high-risk groups.
【作者单位】： 首都医科大学大兴教学医院病理科;首都医科大学大兴教学医院妇产科;北京大学人民医院妇产科;北京大学人民医院病理科;
【基金】：首都卫生发展科研专项项目(2014-3-7122)
【分类号】：R737.33
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