妊娠合并白血病27例临床分析

发布时间：2018-07-29 13:52

【摘要】：目的探讨妊娠合并白血病患者的临床处理及妊娠结局。方法收集27例妊娠合并白血病患者的临床资料,回顾性分析其孕期特点、临床处理及妊娠结局进行分析。结果 (1)孕期临床处理及妊娠结局:孕前诊断9例,8例均足月分娩,1例在孕早期流产后继续化疗。孕早期诊断3例:2例流产后化疗,1例足月分娩。孕中期诊断11例:6例足月分娩,1例死亡,4例行引产后化疗。孕晚期诊断的共4例,均足月分娩。(2)母婴随访情况:失访5例,其余随访时间6~144月,母亲12例存活,10例死亡;27例中有19例活产,分娩后胎儿Apgar评分均7分,随访至今仍健在,未发现胎儿畸形、发育不良、白血病等病史。结论白血病患者在病情缓解后慎重妊娠,可望得到较好的妊娠结局。白血病本身及治疗对于胎儿及孕妇存在一定风险,需要在有条件的综合性医院进行治疗及监管。
[Abstract]:Objective to investigate the clinical management and pregnancy outcome of pregnant women with leukemia. Methods the clinical data of 27 cases of pregnancy complicated with leukemia were analyzed retrospectively. Results (1) the clinical management and outcome of pregnancy: 9 cases were diagnosed before pregnancy and 8 cases were given full term delivery. 1 case continued chemotherapy after early abortion. The diagnosis of early pregnancy was 3 cases: 2 cases of abortion and 1 case of term delivery. The diagnosis of midpregnancy was 11 cases: 6 cases of full-term delivery and 1 case of death. 4 cases were treated with chemotherapy after induced labor. 4 cases were diagnosed in the third trimester of pregnancy. (2) Follow-up of mother and infant: 5 cases lost visit, the remaining follow-up time was 6 ~ 144 months, 19 out of 27 cases died of 12 cases survived, the Apgar score of fetus after delivery was 7 points, and the follow-up is still alive up to now. No history of fetal malformation, dysplasia and leukemia was found. Conclusion Leukemia patients are expected to get a better pregnancy outcome after remission. Leukemia itself and treatment have certain risks to fetus and pregnant women, and need to be treated and supervised in conditional general hospitals.
【作者单位】：福建医科大学附属协和医院妇产科;
【分类号】：R714.25;R733.7

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