血栓弹力图预测早期复发性流产的研究

发布时间：2018-08-12 18:19

【摘要】：目的比较早期复发性流产(RSA)患者及正常妇女血栓弹力图参数的变化,为早期RSA诊断和治疗提供有效的检测指标。方法对62例RSA患者和72例正常生育期妇女进行孕前及孕后的血栓弹力图(TEG)检测,统计各组TEG参数及妊娠丢失率的差异。结果 RSA组与正常组相比,最大凝块振幅(MA)显著增高,差异有统计学意义(t=2.37,P0.05),其余指标两组间差异无统计学意义(t值分别为1.62、1.16、1.64,P0.05)。早孕期,RSA治疗组与正常组的血栓弹力图各参数差异无统计学意义(t值分别为1.57、1.34、1.16、0.54,均P0.05)。RSA未治疗组MA值均显著高于正常组、RSA治疗组(t值分别为2.65、3.21,均P0.05),且R值显著降低(t值分别为2.21、2.37,均P0.05),其余参数每两组之间比较无显著性差异(t值0.45~1.57,均P0.05)。妊娠丢失率方面,正常组、RSA治疗组及未治疗组相比较,妊娠丢失率依次升高,两组间比较差异有统计学意义(χ2值分别为5.33、26.89、6.12,均P0.05)。结论血栓弹力图可在非妊娠时鉴别部分RSA的女性是否处在血栓前状态。在这样状态下未经治疗的RSA再次妊娠流产的风险增高。监测TEG有助于指导RSA高危患者行抗血小板治疗。
[Abstract]:Objective to compare the changes of thromboelastogram parameters in (RSA) patients with early recurrent abortion and normal women, and to provide an effective index for the diagnosis and treatment of early RSA. Methods 62 cases of RSA and 72 cases of normal pregnant women were examined with thromboelastogram (TEG) before and after pregnancy. The TEG parameters and pregnancy loss rate of each group were analyzed. Results compared with the normal group, the maximum clot amplitude (MA) in the RSA group was significantly higher than that in the normal group (t = 2.37, P 0.05), but there was no significant difference between the other two groups (t = 1.62, 1.16, 1.64, P 0.05). There was no significant difference in the parameters of thromboelastogram between the RSA treatment group and the normal group (t = 1.57 卤1.34, P < 0.05). The MA value of RSA untreated group was significantly higher than that of the normal group (t value was 2.65 卤3.21, P0.05), and the R value was significantly lower (t value was significantly lower than that in the normal group (t value was 2.65 卤3.21, respectively). The values were 2.21 and 2.37, respectively (P0.05), and there was no significant difference in the other parameters between the two groups (t value 0.45 卤1.57, P0.05). The pregnancy loss rate in the normal group was significantly higher than that in the untreated group (蠂 ~ 2 = 5.33 卤26.89, P 0.05), and the pregnancy loss rate was significantly higher in the normal group than that in the untreated group (蠂 ~ 2 = 5.33 卤26.89, P < 0.05). Conclusion Thromboelastography can distinguish partial RSA women from prethrombotic status during non-pregnancy. Untreated RSA in this state increases the risk of repregnancy. Monitoring TEG is helpful to guide high-risk RSA patients with anti-platelet therapy.
【作者单位】：莱西市人民医院产科;潍坊市人民医院;青岛市市立医院妇科;
【分类号】：R714.21

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