外周血促肾上腺皮质激素释放激素浓度与先兆早产的相关性及其影响因素

发布时间：2018-11-18 21:37

【摘要】：目的检测先兆早产患者外周血促肾上腺皮质激素释放激素(CRH)浓度,探讨其浓度与先兆早产症状的相关性及影响其浓度的因素,以探讨CRH浓度作为预测早产指标的可行性。方法选取先兆早产住院孕妇及不足月非先兆早产原因住院孕妇共45例,其中先兆早产组(孕28~36周)22例,对照组(孕28~36周、无先兆早产症状的孕妇)23例。采每位受试对象抗凝外周血5 m L,分离血浆,采用ELISA法测定CRH浓度。结果先兆早产组孕妇外周血CRH浓度与对照组孕妇相比显著升高(P0.01)。先兆早产组与对照组的新生儿出生Apgar评分(1和5 min)均7分,且2组比较新生儿出生Apgar评分无统计学差异(P0.05)。先兆早产组与对照组比较,宫颈Bishop评分无统计学差异(P0.05),先兆早产组中CRH浓度与宫颈Bishop评分无明显关系(P0.05)。先兆早产组与对照组中,双胎者与单胎者相比,胎膜早破者与非胎膜早破者相比,CRH浓度的差异均有统计学意义(均P0.05)。结论血浆CRH浓度明显升高是先兆早产的显著指标。血浆CRH浓度不影响新生儿出生状态和宫颈成熟度,但受妊娠胎儿数影响,且与胎膜早破密切相关。血浆CRH浓度有望成为预测先兆早产的指标,但其影响因素较多,应在分析其影响因素后进一步研究其预测定量值。
[Abstract]:Objective to detect the concentration of adrenocorticotropin releasing hormone (CRH) in peripheral blood of patients with threatened preterm delivery, to explore the correlation between the concentration of CRH and symptoms of threatened preterm delivery and the factors affecting its concentration, and to explore the feasibility of using CRH concentration as a predictor of preterm labor. Methods A total of 45 hospitalized pregnant women with threatened preterm delivery and unthreatened preterm delivery were selected, including 22 patients in threatened preterm delivery group (2836 weeks of pregnancy) and 23 in control group (2836 weeks of gestation without symptoms of preterm delivery). 5 mL of anticoagulant peripheral blood was collected from each subject, plasma was isolated and CRH concentration was determined by ELISA method. Results the concentration of CRH in peripheral blood of threatened premature delivery group was significantly higher than that of control group (P0.01). The neonatal Apgar score (1 and 5 min) in the threatened preterm delivery group and the control group were 7, and there was no significant difference in the neonatal Apgar score between the two groups (P0.05). There was no significant difference in cervical Bishop score between threatened premature delivery group and control group (P0.05). There was no significant relationship between CRH concentration and cervical Bishop score in threatened preterm delivery group (P0.05). In the threatened premature delivery group and the control group, there were significant differences in the concentration of CRH between twin and single fetus, premature rupture of membranes and non-premature rupture of membranes (P0.05). Conclusion the increase of plasma CRH concentration is a significant indicator of threatened premature delivery. The concentration of plasma CRH does not affect the birth status and cervical maturity of the newborn, but it is affected by the number of fetuses in pregnancy and is closely related to premature rupture of membranes. Plasma CRH concentration is expected to be a predictor of preterm labor, but there are many influencing factors, so we should further study the quantitative value of plasma CRH after analyzing its influencing factors.
【作者单位】：中国医科大学附属盛京医院妇产科;
【分类号】：R714.21

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