良性转移性平滑肌瘤6例临床病理分析

发布时间：2018-11-23 09:06

【摘要】：目的探讨良性转移性平滑肌瘤(BML)的临床病理特征、诊断与鉴别诊断。方法回顾性分析6例BML患者的临床资料和组织病理学特点,对肿瘤组织进行光镜观察及免疫组化研究。结果6例BML均为女性,平均50.2岁。5例子宫平滑肌瘤术后7～18年发生转移,其中1例同时发现原发灶和转移灶。肺转移5例,其中1例伴有腰椎转移,另1例为腹腔淋巴结转移,复查子宫手术后病理切片证实为良性平滑肌瘤,肺、淋巴结及腰椎肿瘤组织形态类似于子宫平滑肌瘤,细胞无异型,未找到核分裂象。免疫组化染色证实为平滑肌源性,雌、孕激素受体(+)。结论BML是一种罕见的发生于有子宫平滑肌瘤手术史的女性,肺是主要转移部位,激素依赖性。该病变病程缓慢,手术切除是主要的治疗手段。
[Abstract]:Objective to investigate the clinicopathological features, diagnosis and differential diagnosis of benign metastatic leiomyoma (BML). Methods the clinical data and histopathological features of 6 patients with BML were retrospectively analyzed. Results all 6 cases of BML were female with an average age of 50.2 years. 5 cases of uterine leiomyoma had metastasis from 7 to 18 years after operation. There were 5 cases of lung metastasis, including 1 case with lumbar vertebra metastasis and 1 case with abdominal lymph node metastasis. The pathological section after uterine operation confirmed benign leiomyoma. The histology of lung, lymph node and lumbar vertebrae tumor was similar to that of uterine leiomyoma. No abnormal cells were found and mitotic signs were not found. Immunohistochemical staining confirmed smooth muscle derived, estrogen and progesterone receptor (). Conclusion BML is a rare occurrence in women with a history of uterine leiomyoma. The lung is the main metastatic site and hormone dependent. The course of the disease is slow, surgical resection is the main treatment.
【作者单位】：中国医学科学院北京协和医学院肿瘤医院肿瘤研究所病理科;
【分类号】：R737.33

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