治疗需氧菌阴道炎的随机对照研究

发布时间：2018-12-14 11:45

【摘要】：目的比较氯喹那多-普罗雌烯阴道片(Chlorquinaldol-Promestriene Vaginal Tablets)与克林霉素对需氧菌阴道炎的疗效及复发率的影响。方法对2009年11月至2010年4月北京大学第一医院妇产科门诊诊断的15~60岁确诊为需氧菌阴道炎(aerobic vaginosis,AV)患者共98例,随机分组治疗(A组:氯喹那多-普罗雌烯阴道片1片/日,睡前置入阴道,连续12 d;B组:克林霉素,300 mg/d,阴道上药,连续12 d),随访1个月,并对所得数据统计分析。结果 (1)治疗后7~10 d显效与治愈者30例,总有效率30.6%,其中A组临床有效率为35.4%(17/48),B组26.0(13/50),两组比较(χ~2=1.022,P=0.312,P0.05),差异无统计学意义;(2)随访1个月后两组的各症状体征P值均大于0.05,差异无统计学意义,疗效判定复发率A组(2/35)5.7%、B组(6/29)20.7%,差异无统计学意义P=0.071。结论氯喹那多-普罗雌烯阴道片在治疗AV中能达到与克林霉素一致的效果,并有减少复发的趋势。
[Abstract]:Objective to compare the effect of Chlorquinaldol-Promestriene Vaginal Tablets) and clindamycin on aerobic vaginitis and its recurrence rate. Methods from November 2009 to April 2010, 98 patients with aerobic vaginitis (aerobic vaginosis,AV) who were diagnosed in outpatient department of gynecology and obstetrics of the first Hospital of Peking University from November 2009 to April 2010 were diagnosed as aerobic vaginitis (aerobic vaginosis,AV). Patients were randomly divided into two groups (group A: chloroquinado-proestrin vaginal tablet 1 tablet per day, vaginal implantation before bedtime, continuous 12 days; Group B: clindamycin, 300 mg/d, vaginal administration, continuous 12 d), follow-up for 1 month, and statistical analysis of the data. Results (1) the total effective rate was 30.6% in group A (26.0% (13 / 50) in 17 / 48), B group). P0.05), the difference was not statistically significant; (2) after 1 month follow-up, the P values of symptoms and signs of the two groups were all greater than 0.05, the difference was not statistically significant. The recurrence rate of group A (2 / 35) was 5.7g and the score of group B (6 / 29) was 20.7. The difference was not statistically significant (P = 0.071). Conclusion chloroquinado-proestrin vaginal tablet can achieve the same effect as clindamycin in the treatment of AV and has a tendency to reduce recurrence.
【作者单位】：北京大学第一医院妇产科;清华大学长庚医院妇产科;

【相似文献】