肿瘤标记物在卵巢良恶性肿瘤鉴别中的意义

发布时间：2018-12-18 03:36

【摘要】：目的分析血清肿瘤标记物糖类抗原(CA125)、癌胚抗原(CEA)、人附睾蛋白4(HE4)在卵巢良恶性肿瘤鉴别中的意义。方法回顾性分析我院自2010年1月至2012年1月间收治的228例卵巢肿瘤患者的临床资料,探讨肿瘤标记物CA125、CEA、HE4在卵巢良恶性肿瘤鉴别中的意义。所有患者均经手术治疗并经术后病理检测确诊,其中,卵巢恶性肿瘤118例,卵巢良性肿瘤110例,所有病例资料完整,均在术前和术后进行了血清肿瘤标记物CA125、CEA、HE4的检查。结果卵巢癌组患者血清CA125、CEA、HE4水平比卵巢良性肿瘤组显著增高,差异具有统计学意义(P0.05);CA125、CEA、HE4诊断卵巢癌的敏感性分别为60.17%、29.66%、40.68%,联合检测的敏感性为88.14%,差异具有有统计学意义(P0.05)。结论血清肿瘤标记物CA125、CEA、HE4联合检测是卵巢良恶性肿瘤鉴别的有效方法,对于卵巢恶性肿瘤的早期诊断有重要意义。
[Abstract]:Objective to analyze the significance of serum tumor marker carbohydrate antigen (CA125) and carcinoembryonic antigen (CEA), human epididymal protein 4 (HE4) in the differential diagnosis of ovarian benign and malignant tumors. Methods the clinical data of 228 patients with ovarian neoplasms from January 2010 to January 2012 were retrospectively analyzed and the significance of tumor marker CA125,CEA,HE4 in differentiating benign and malignant ovarian tumors was discussed. All the patients were confirmed by surgical treatment and pathological examination after operation. 118 cases of malignant ovarian tumor and 110 cases of benign ovarian tumor were diagnosed. The data of all cases were complete. The serum tumor marker CA125,CEA,HE4 was examined before and after operation. Results the serum CA125,CEA,HE4 level in ovarian cancer group was significantly higher than that in benign ovarian tumor group (P0.05). The sensitivity of CA125,CEA,HE4 in the diagnosis of ovarian cancer was 60.17 and 29.66 respectively. The sensitivity of combined detection was 88.14. The difference was statistically significant (P0.05). Conclusion the combined detection of serum tumor marker CA125,CEA,HE4 is an effective method for the differential diagnosis of ovarian benign and malignant tumors, and is of great significance for the early diagnosis of ovarian malignant tumors.
【作者单位】：郑州市卫生学校;
【分类号】：R737.31

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