系统性红斑狼疮妊娠时机对妊娠结局影响的meta分析

发布时间：2018-12-26 19:46

【摘要】：目的:系统评价妊娠时机选择对妊娠合并系统性红斑狼疮(SLE)患者妊娠结局的影响。方法:计算机检索CNKI数据库、万方数据库、中国生物医学文献数据库、Pubmed、EMBAS、OVID等数据库,检索2000~2016年公开发表的妊娠时机的选择对妊娠合并SLE妊娠结局影响的相关研究报道,对妊娠时机的选择对妊娠合并SLE妊娠结局的影响进行合并分析。结果:纳入13篇研究共554例患者。Meta分析结果显示:在胎儿丢失率方面,选择性妊娠与非选择性妊娠比较差异有统计学意义(OR=0.09,95%CI为0.05~0.15,P0.001);在病情恶化方面,选择性妊娠与非选择性妊娠比较差异有统计学意义(OR=0.08,95%CI为0.04~0.14,P0.001);在胎儿发育迟缓方面,选择性妊娠与非选择性妊娠比较差异有统计学意义(OR=0.18,95%CI为0.09~0.39,P0.001);在子痫前期发生率方面,选择性妊娠与非选择性妊娠比较差异无统计学意义(OR=1.08,95%CI为0.37~3.17,P=0.89);在早产率方面,选择性妊娠与非选择性妊娠比较差异有统计学意义(OR=0.26,95%CI为0.17~0.39,P0.001)。结论:SLE病情稳定期选择妊娠,母婴可获得良好的妊娠结局。
[Abstract]:Objective: to evaluate the influence of pregnancy timing on pregnancy outcome in patients with systemic lupus erythematosus (SLE). Methods: CNKI database, Wanfang database, Chinese biomedical literature database, Pubmed,EMBAS,OVID database and so on were searched, and related research reports on the influence of the choice of pregnancy timing published from 2000 to 2016 on pregnancy outcome of pregnancy complicated with SLE were searched. The influence of pregnancy timing on pregnancy outcome with SLE was analyzed. Results: a total of 554 patients were included in 13 studies. The results of Meta analysis showed that there was a significant difference between selective pregnancy and non-selective pregnancy in fetal loss rate (OR=0.09,95%CI = 0.05 0.15p 0.001). The difference between selective pregnancy and non-selective pregnancy was statistically significant (OR=0.08,95%CI = 0.04 卤0.14, P0.001). In the aspect of fetal growth retardation, the difference between selective pregnancy and non-selective pregnancy was statistically significant (OR=0.18,95%CI = 0.09 ~ 0.39 / P0.001). In the incidence of preeclampsia, there was no significant difference between selective pregnancy and non-selective pregnancy (OR=1.08,95%CI = 0.37 ~ 3.17). In the aspect of premature delivery, the difference between selective pregnancy and non-selective pregnancy was statistically significant (OR=0.26,95%CI = 0.17 ~ 0.39 / P0.001). Conclusion: the pregnancy is selected in stable stage of SLE, and the mother and infant can obtain a good pregnancy outcome.
【作者单位】：华北理工大学附属唐山市工人医院;
【基金】：2013年唐山市科技计划项目(No:13130267b)
【分类号】：R714.25

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