子宫内膜癌患者细菌感染与炎症因子的表达

发布时间：2019-03-14 20:08

【摘要】：目的探讨子宫内膜癌患者细菌感染及炎症因子白细胞介素-6(IL-6)、白细胞介素-11(IL-11)的表达,分析子宫内膜癌的发生与局部微环境中的炎症变化的关系,以揭示炎症在子宫内膜癌的发生及发展中的机制。方法选取医院2011年6月-2013年6月子宫内膜癌(研究组)与子宫肌瘤患者(对照组)各40例,采集宫颈分泌物及子宫内膜组织进行细菌培养,以免疫组化染色法检测子宫内膜组织中的IL-6、IL-11的表达。结果研究组患者宫颈分泌物、子宫内膜组织中细菌培养阳性率分别为40.00%、30.00%,高于对照组的15.00%、5.00%,两组细菌培养阳性率比较差异有统计学意义(P0.05);子宫内膜癌患者低分化、中分化、高分化时子宫内膜组织细菌培养阳性率分别为25.00%、33.33%、28.57%,FIGO分期Ⅰ期、Ⅱ期时子宫内膜组织细菌培养阳性率分别为29.41%、33.33%,不同分化程度、分期子宫内膜组织中细菌培养阳性率比较差异无统计学意义;研究组子宫内膜组织中IL-6、IL-11阳性表达明显高于对照组,差异有统计学意义(P0.05)。结论子宫内膜癌组织中细菌培养阳性率高于正常子宫内膜组织,炎症因子IL-6、IL-11阳性表达升高,提示感染及炎症因子可能参与了子宫内膜癌的发病过程。
[Abstract]:Objective to investigate the bacterial infection and the expression of interleukin-6 (IL-6) and interleukin-11 (IL-11) in patients with endometrial carcinoma, and to analyze the relationship between the occurrence of endometrial carcinoma and the changes of inflammation in the local microenvironment. In order to reveal the mechanism of inflammation in the pathogenesis and development of endometrial carcinoma. Methods from June 2011 to June 2013, 40 patients with endometrial carcinoma (study group) and 40 patients with uterine leiomyoma (control group) were selected to collect cervical secretions and endometrial tissue for bacterial culture. Immunohistochemical staining was used to detect the expression of IL-6,IL-11 in endometrial tissue. Results the positive rates of bacterial culture in cervical secretions and endometrium were 40.00% and 30.00% respectively in the study group, which were higher than those in the control group (15.00%, 5.00%). There was significant difference in the positive rate of bacterial culture between the two groups (P0.05). The positive rates of bacterial culture in endometrial tissue were 25.00%, 33.33%, 28.57% at low differentiation, middle differentiation and high differentiation, respectively, and Figo stage 鈪，

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