坤泰胶囊与激素补充疗法联合治疗绝经综合征的临床疗效及安全性

发布时间：2019-03-20 17:10

【摘要】：目的探讨坤泰胶囊联合雌激素补充疗法治疗绝经综合征的临床疗效及安全性。方法选取2012年6月至2014年6月在该院门诊就诊的120例绝经综合征患者,将其按照随机数字法随机分为对照组和观察组,每组60例,观察组给予补佳乐1 mg,1次/d,且口服坤泰胶囊4粒/次,3次/d;对照组给予常规药物补佳乐2 mg,1次/d;两组均治疗3个月,观察两组临床疗效及安全性。结果对照组治疗后FSH、LH、E2与治疗前相比均显著变化(t=14.559 2、14.163 3、17.202 8,P0.05),但观察组治疗后FSH、LH、E2与治疗前相比变化更显著(t=19.228 4、8.039 4、29.5131,P0.05);且观察组治疗后FSH显著低于对照组,E2显著高于对照组(t=4.723 3、9.593 9,P0.05)。与治疗前相比,两组治疗后阴道细胞成熟值及子宫内膜厚度变化显著t=6.339 5、12.202 4、3.508 3、17.832 8,P0.05);观察组治疗后子宫内膜厚度显著高于对照组,但阴道细胞成熟值显著低于对照组(t=3.015 6、5.241 1,P0.05)。治疗3个月后,观察组治疗总有效率显著高于对照组(χ2=8.539,P0.05)。用药期间血常规、肝、肾功能检查均未发现异常;常见的不良反应主要是乳房胀痛、阴道出血及消化道反应,两组不良反应比较有统计学差异(χ2=4.227,P0.05)。结论坤泰胶囊联合雌激素补充疗法治疗绝经综合征临床疗效确切,值得推广。
[Abstract]:Objective to investigate the clinical efficacy and safety of Kuntai capsule combined with estrogen supplement therapy in the treatment of menopausal syndrome. Methods from June 2012 to June 2014, 120 patients with menopausal syndrome were randomly divided into two groups: control group (n = 60) and observation group (n = 60). And oral Kuntai capsule 4 times, 3 times per day; The control group was treated with routine medicine BujiaLe for 2 mg,1 / d, and the two groups were treated for 3 months to observe the clinical efficacy and safety of the two groups. Results the changes of FSH,LH,E2 in the control group were significant after treatment (t = 14.559,14.163,17.202.8, P0.05), but the changes of FSH,LH,E2 in the observation group after treatment were more significant than those before treatment (t = 19.2284,8.039,29.5131, P < 0.01). (P 0.05); After treatment, the FSH in the observation group was significantly lower than that in the control group, while E 2 was significantly higher in the observation group than in the control group (t = 4.723, 9.5939, P0.05). Compared with pre-treatment, the changes of vaginal cell maturation and endometrial thickness after treatment in the two groups were significant (t = 6.339,12.204,3.508,17.8328, P0.05). The endometrial thickness in the observation group was significantly higher than that in the control group after treatment, but the vaginal cell maturation value was significantly lower than that in the control group (t = 3.0156, 5.241 1, P0.05). After 3 months treatment, the total effective rate in the observation group was significantly higher than that in the control group (蠂 2 = 8.539, P0.05). Blood routine, liver and renal function were not found abnormal during the drug use. The common adverse reactions were breast distension, vaginal bleeding and digestive tract reaction. There was statistical difference between the two groups (蠂 2, 4.227, P0.05). Conclusion Kuntai capsule combined with estrogen supplement therapy is effective in the treatment of menopause syndrome, and it is worth popularizing.
【作者单位】：湖北民族学院附属民大医院妇科;
【分类号】：R711.75

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