孕妇毒死蜱暴露水平评估及影响因素分析
发布时间：2019-04-09 08:31
【摘要】：目的研究孕妇尿中毒死蜱(chlorpyrifos,CPF)暴露水平及其影响因素,为评估宫内CPF暴露对儿童健康影响提供科学依据。方法于2009年6月—2010年1月选取江苏省某县1 100名孕妇为研究对象,采集孕妇尿样并完成调查问卷,以气相色谱-串联质谱法(GC-MS/MS)检测尿中CPF代谢物3,5,6-三氯-2-吡啶醇(3,5,6-trichloro-2-pyridinol,TCPy)浓度,估算孕妇CPF的每日摄入量(absorbed daily dose,ADD)并分析其影响因素。结果孕妇尿中TCPy检出率为100%,TCPy肌酐校正浓度范围为0.14~135.44μg/g Cr,中位值为6.96μg/g Cr,高于国外研究报道水平;估算的ADD中位值为0.31μg/(kg·d),低于农药残留联席会议(Joint Meeting of Pesticide Residues,JMPR)制定的每日允许摄入量[0.01 mg/(kg·d)],但有51.4%的孕妇ADD值超过了美国环保局(Environmental Protection Agency,EPA)制定的慢性参考剂量[chronic reference doses,0.3μg/(kg·d)]。统计分析显示孕妇体内CPF负荷水平与工作类型、家庭收入、居住地类型和季节等因素有关。结论该地区孕妇普遍暴露于CPF农药,半数以上孕妇ADD水平高于EPA制定的慢性参考剂量,提示母婴有农药暴露的潜在健康风险。孕妇工作类型、家庭收入、居住地环境和季节是影响孕妇CPF暴露水平的主要因素。
[Abstract]:Objective to study the levels of urinary chlorpyrifos (chlorpyrifos,CPF) exposure in pregnant women and its influencing factors in order to provide a scientific basis for assessing the effects of intrauterine CPF exposure on children's health. Methods from June 2009 to January 2010, 1 100 pregnant women in a county of Jiangsu Province were selected as subjects. Urine samples of pregnant women were collected and questionnaires were completed. Urine CPF metabolites 3,5,5 were detected by gas chromatography-tandem mass spectrometry (GC-MS/MS). The concentration of 6-trichloro-2-pyridinol (3, 5, 6-trichloro-2-pyridinol, TCPy) was used to estimate the daily intake of CPF in pregnant women (absorbed daily dose,ADD) and its influencing factors were analyzed. Results the detection rate of TCPy in urine of pregnant women was 100%. The median concentration of TCPy creatinine was 0.14 ~ 135.44 渭 g / g Cr,. The median value was 6.96 渭 g / g Cr, which was higher than that reported by foreign studies. The estimated median value of ADD was 0.31 渭 g / (kg 路d), lower than the ADI set by the Joint meeting on Pesticide residues (Joint Meeting of Pesticide Residues,JMPR) [0.01 mg/ (kg 路d)], However, 51.4% of pregnant women with ADD exceeded the chronic reference dose [chronic reference doses, 0.3 渭 g / (kg 路d)] set by the U.S. Environmental Protection Agency (Environmental Protection Agency,EPA). Statistical analysis showed that the level of CPF load in pregnant women was related to the type of work, family income, residence type and season. Conclusion pregnant women in this area are generally exposed to CPF pesticides, and more than half of pregnant women have higher levels of ADD than the chronic reference dose established by EPA, suggesting that there is a potential health risk for maternal and infant exposure to pesticides. The type of work, family income, living environment and season of pregnant women were the main factors influencing the level of CPF exposure of pregnant women.
【作者单位】： 复旦大学公共卫生学院国民健康社会风险预警协同创新中心教育部公共卫生安全重点实验室;上海市疾病预防控制中心;
【基金】：上海市自然科学基金(11ZR1402200)
【分类号】：R446.12;R714.2
，
本文编号：2455003
[Abstract]:Objective to study the levels of urinary chlorpyrifos (chlorpyrifos,CPF) exposure in pregnant women and its influencing factors in order to provide a scientific basis for assessing the effects of intrauterine CPF exposure on children's health. Methods from June 2009 to January 2010, 1 100 pregnant women in a county of Jiangsu Province were selected as subjects. Urine samples of pregnant women were collected and questionnaires were completed. Urine CPF metabolites 3,5,5 were detected by gas chromatography-tandem mass spectrometry (GC-MS/MS). The concentration of 6-trichloro-2-pyridinol (3, 5, 6-trichloro-2-pyridinol, TCPy) was used to estimate the daily intake of CPF in pregnant women (absorbed daily dose,ADD) and its influencing factors were analyzed. Results the detection rate of TCPy in urine of pregnant women was 100%. The median concentration of TCPy creatinine was 0.14 ~ 135.44 渭 g / g Cr,. The median value was 6.96 渭 g / g Cr, which was higher than that reported by foreign studies. The estimated median value of ADD was 0.31 渭 g / (kg 路d), lower than the ADI set by the Joint meeting on Pesticide residues (Joint Meeting of Pesticide Residues,JMPR) [0.01 mg/ (kg 路d)], However, 51.4% of pregnant women with ADD exceeded the chronic reference dose [chronic reference doses, 0.3 渭 g / (kg 路d)] set by the U.S. Environmental Protection Agency (Environmental Protection Agency,EPA). Statistical analysis showed that the level of CPF load in pregnant women was related to the type of work, family income, residence type and season. Conclusion pregnant women in this area are generally exposed to CPF pesticides, and more than half of pregnant women have higher levels of ADD than the chronic reference dose established by EPA, suggesting that there is a potential health risk for maternal and infant exposure to pesticides. The type of work, family income, living environment and season of pregnant women were the main factors influencing the level of CPF exposure of pregnant women.
【作者单位】： 复旦大学公共卫生学院国民健康社会风险预警协同创新中心教育部公共卫生安全重点实验室;上海市疾病预防控制中心;
【基金】：上海市自然科学基金(11ZR1402200)
【分类号】：R446.12;R714.2
，
本文编号：2455003
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