骨膜蛋白在子宫内膜癌的肿瘤干细胞中裸鼠成瘤性的实验研究
发布时间：2019-05-11 14:17
【摘要】：目的探讨骨膜蛋白在子宫内膜癌的肿瘤干细胞中裸鼠成瘤特性。方法用免疫磁珠技术分离出骨膜蛋白,分别在30只裸鼠的左、右腋背部,皮下注射骨膜蛋白阳性细胞、骨膜蛋白阴性细胞,用流式细胞仪检测后进行计数,观察其中骨膜蛋白阳性细胞的比例。结果在35.7%(5/14)裸鼠胞浆内有骨膜蛋白表达,在正常子宫内膜组织中未见阳性表达;注射骨膜蛋白阳性细胞裸鼠的肿块重量、体积及瘤体骨膜蛋白阳性表达显著高于注射骨膜蛋白阴性细胞的裸鼠(P0.05)。结论骨膜蛋白阳性的子宫内膜癌细胞在裸鼠体内具有成瘤性,而骨膜蛋白阴性细胞不具有成瘤性。
[Abstract]:Objective to investigate the tumorigenic characteristics of periosteal protein in tumor stem cells of endometrial carcinoma in nude mice. Methods the periosteal protein was isolated by immunomagnetic beads technique. Periosteal protein positive cells and periosteal protein negative cells were subcutaneously injected into the left and right axils of 30 nude mice. The proportion of periosteal protein positive cells was observed. Results the expression of periosteal protein was found in 35.7% (5 鈮，
本文编号：2474561
[Abstract]:Objective to investigate the tumorigenic characteristics of periosteal protein in tumor stem cells of endometrial carcinoma in nude mice. Methods the periosteal protein was isolated by immunomagnetic beads technique. Periosteal protein positive cells and periosteal protein negative cells were subcutaneously injected into the left and right axils of 30 nude mice. The proportion of periosteal protein positive cells was observed. Results the expression of periosteal protein was found in 35.7% (5 鈮，
本文编号：2474561
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