宫颈癌应用放化疗联合复方苦参注射液治疗对细胞免疫功能影响分析

发布时间：2019-07-22 21:24

【摘要】：目的:通过观察放化疗联合复方苦参注射液治疗宫颈癌临床疗效及对患者细胞免疫功能及生活质量影响,从而为临床宫颈癌患者治疗提供有力依据。方法:按照随机数字表法将诊断为80例Ⅲa~Ⅳ期宫颈癌患者分组为对照组与治疗组,各40例。对照组采用放化疗治疗;治疗组于放化疗治疗基础上加用复方苦参注射液治疗;28 d为1个周期,2组均治疗3个周期。于治疗前及治疗后第2天检测2组患者细胞免疫功能,统计2组患者临床疗效、生活质量、不良反应。结果:经治疗3个周期后,治疗组CD3+、CD4+、NK细胞及CD4+/CD8+值较治疗前明显提高,而CD8+值较治疗前明显下降,且优于对照组,P0.05;对照组CD8+及NK细胞数较治疗前稍增加,其他指标较治疗前略下降,P0.05。治疗组总有效者19例(总有效率为47.5%)明显高于对照组13例(32.5%),P0.05。治疗组生存质量改善者为37例(改善率为92.5%)明显高于对照组29例(72.5%),P0.05;治疗组不良反应率明显低于对照组,P0.05。结论:应用复方苦参注射液联合放化疗治疗宫颈癌,其可减少不良反应,增强患者细胞免疫功能,从而提高临床疗效及患者生活质量。
[Abstract]:Objective: to observe the clinical efficacy of radiotherapy and chemotherapy combined with compound Sophora flavescens injection in the treatment of cervical cancer and its effect on cellular immune function and quality of life, so as to provide a powerful basis for the treatment of cervical cancer. Methods: according to the random digital table method, 80 patients with stage III a ~ IV cervical cancer were divided into control group (n = 40) and treatment group (n = 40). The control group was treated with radiotherapy and chemotherapy, and the treatment group was treated with compound Sophora flavescens injection on the basis of radiotherapy and chemotherapy. 28 days was one cycle, and both groups were treated for 3 cycles. The cellular immune function of the two groups was measured before and 2 days after treatment, and the clinical efficacy, quality of life and adverse reactions of the two groups were counted. Results: after three cycles of treatment, the values of CD3, CD4, NK cells and CD4 / CD8 in the treatment group were significantly higher than those before treatment, while the values of CD8 were significantly lower than those before treatment, and were better than those in the control group (P0.05). The number of CD8 and NK cells in the control group was slightly higher than that before treatment, and the other indexes were slightly lower than those before treatment (P0.05). The total effective rate in the treatment group (47.5%) was significantly higher than that in the control group (32.5%). The improvement rate of quality of life in the treatment group (92.5%) was significantly higher than that in the control group (72.5%), P0.05, and the adverse reaction rate in the treatment group was significantly lower than that in the control group (P0.05). Conclusion: the treatment of cervical cancer with compound Sophora flavescens injection combined with radiotherapy and chemotherapy can reduce the adverse reactions and enhance the cellular immune function of the patients, so as to improve the clinical efficacy and quality of life of the patients.
【作者单位】：武警浙江总队杭州医院肿瘤科;
【分类号】：R737.33

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