假丝酵母菌性阴道炎联合治疗的疗效分析

发布时间：2019-08-12 18:28

【摘要】：目的了解制霉菌素阴道泡腾片、硝夫太尔片联合重组人干扰素α2b栓治疗假丝酵母菌性阴道炎的疗效,为临床用药提供参考。方法选择2010年7月-2014年6月就诊的假丝酵母菌性阴道炎患者152例,其中,初发性患者85例、复发性患者67例,将初发性患者随机分为初发性观察组46例和初发性对照组39例;将复发性患者随机分为复发性观察组37例和复发性对照组30例;给予初发性观察组和复发性观察组制霉菌素阴道泡腾片、硝夫太尔片和重组人干扰素α2b栓;给予初发性对照组和复发性对照组克霉唑栓;采集患者的阴道分泌物标本进行菌种鉴定和药敏试验,治疗两个疗程后评价疗效。结果从患者标本中检出157株假丝酵母菌,构成比最高的为白色假丝酵母菌,占66.88%;白色假丝酵母菌对两性霉素B、制霉菌素、伏立康唑、氟胞嘧啶的耐药率均10.00%;初发性观察组的治愈率67.39%,总有效率95.65%,与初发性对照组的差异均无统计学意义;复发性观察组的治愈率21.62%,总有效率81.08%,均高于复发性对照组(P0.05)。结论制霉菌素阴道泡腾片、硝夫太尔片联合重组人干扰素α2b栓,可有效治疗假丝酵母菌性阴道炎。
[Abstract]:Objective to investigate the efficacy of nystatin vaginal effervescent tablets, Neftaire tablets combined with recombinant human interferon 伪 2b suppository in the treatment of candida vaginitis, and to provide reference for clinical use. Methods 152 patients with candida vaginitis from July 2010 to June 2014 were selected, including 85 primary patients and 67 recurrent patients. The patients were randomly divided into primary observation group (n = 46) and primary control group (n = 39), and recurrent patients were randomly divided into recurrent observation group (n = 37) and recurrent control group (n = 30). The patients in the primary observation group and the recurrent observation group were given nystatin vaginal effervescent tablets, nifetil tablets and recombinant human interferon 伪 2b suppository; the primary control group and recurrent control group were given clotrimazole suppository; the vaginal secretions of the patients were collected for strain identification and drug sensitivity test, and the curative effect was evaluated after two courses of treatment. Results 157 strains of candida albicans were detected from the patients, the highest constituent ratio was candida albicans, accounting for 66.88%, the resistance rate of candida albicans to amphotericin B, nystatin, vericonazole and fluorocytosine was 10.00%, and the cure rate and total effective rate of the primary observation group were 67.39% and 95.65%, respectively, which were not significantly different from those of the primary control group. The cure rate and total effective rate of recurrent observation group were 21.62% and 88.08%, respectively, which were higher than those of recurrent control group (P 0.05). Conclusion Nystatin vaginal effervescent tablets, Neftaire tablets combined with recombinant human interferon 伪 2b suppository can effectively treat candida vaginitis.
【作者单位】：诸暨市计划生育技术指导站妇产科;
【基金】：浙江省卫生厅基金资助项目(2013KYB266)
【分类号】：R711.31

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