肾损伤分子-1、β2-微球蛋白、内皮素-1和肌酐在妊娠期高血压疾病并发急性肾损伤的临床研究

发布时间：2018-03-30 12:58

本文选题：子痫前期　切入点：肾损伤　出处：《生殖与避孕》2016年03期

【摘要】：目的:探讨血清肌酐(SCr)、内皮素-1(ET-1)、肾损伤分子-1(KIM-1)和β2-微球蛋白(β2-MG)的水平在妊娠期高血压疾病并发早期肾损伤的临床意义。方法:将妊娠期高血压疾病并发肾损伤的孕产妇40例设为肾病组,同期正常孕产妇40例设为对照组,分别在孕龄30周、32周、34周、36周检测孕妇血SCr、ET-1、尿KIM-1和β2-MG的水平。结果:1肾病组与对照组比较,患者的年龄、孕次和流产史均无统计学差异(P0.05),尿量、尿素氮(BUN)、SCr及尿蛋白定量均存在统计学差异(P0.001);2肾病组和对照组整体比较,SCr、ET-1、KIM-1和β2-MG的组间、时间点间的交互作用均有统计学差异(P0.05);3孕36周SCr、孕32周KIM-1及孕34周ET-1和β2-MG水平肾病组与对照组组间存在统计学差异(P0.05);4对照组组内不同孕周间SCr、ET-1、KIM-1和β2-MG水平无统计学差异(P0.05);肾病组组内与孕30周时比,KIM-1水平在孕32周显著升高(P0.05),在孕34周、36周进一步升高(P0.01);ET-1和β2-MG水平在孕34周显著升高(P0.05),而SCr在孕36周显著升高(P0.05)。结论:妊娠期高血压疾病孕妇产前监控中,联合检测SCr、ET-1、KIM-1和β2-MG能及时发现肾损伤的存在;妊娠期高血压疾病并发肾损伤时KIM-1、ET-1和β2-MG的改变早于SCr的改变。
[Abstract]:Objective: to investigate the clinical significance of serum creatinine creatinine (SCR), endothelin-1 (ET-1), renal injury molecule (-1) KIM-1) and 尾 2-microglobulin (尾 2-MG) in patients with hypertensive disorder complicating pregnancy with early renal injury. 40 cases of pregnant and parturient women were divided into nephropathy group, During the same period, 40 normal pregnant and parturient women were set up as control group. The levels of serum SCr-ET-1, urinary KIM-1 and 尾 2-MG were measured at 30 weeks, 32 weeks, 34 weeks and 36 weeks of gestational age, respectively. Results the age of the patients in the control group was compared with that in the control group. There was no significant difference in pregnancy and abortion history (P 0.05), urine volume, bun bun bun, SCR and urinary protein were significantly different between the control group and the control group. There was no significant difference between the control group and the control group, and there was no significant difference between the two groups, and there was no significant difference between the two groups, and there was no significant difference between the two groups. There were significant differences in the interaction between time points (P 0.05), KIM-1 at 32 weeks and ET-1 and 尾 2-MG levels at 34 weeks after gestation. There was no statistical difference in the levels of SCr-ET-1KIM-1 and 尾 2-MG between nephropathy group and control group during different gestational weeks. The level of KIM-1 in nephropathy group was significantly higher than that in gestational group at 32 weeks after gestation. The levels of ET-1 and 尾 2-MG were further increased at 34th week of gestation, and the levels of 尾 2-MG increased significantly at 34th week of gestation, while SCr significantly increased P0.05 at 36-week gestation. Conclusion: high blood level in gestational period is significantly higher than that of P0.050.Conclusion: high blood level in gestational period is significantly higher than that in group B at 34th week of gestation. During prenatal monitoring of pregnant women with diseases, Combined detection of KIM-1 and 尾 2-MG could detect the presence of renal injury in time, and the changes of KIM-1 et 1 and 尾 2-MG in hypertensive disorder complicating pregnancy with renal injury were earlier than those of SCr.
【作者单位】：湖北医药学院附属襄阳医院;
【分类号】：R714.246

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