胸主动脉内血液流动的计算流体力学方法研究
发布时间：2018-12-07 19:13
【摘要】： 目的 结合医学图像三维重构技术和计算流体力学(CFD)研究方法对人体胸主动脉内血液流动进行三维数值模拟并获取相应的血流动力学参数,通过对不同个体(包括正常和异常患者)胸主动脉内血液流动分析来探讨血流动力学参数对主动脉脉管疾病如动脉粥样硬化、动脉夹层等疾病的影响,为其各种脉管疾病的发病机理提供理论依据以及对脉管疾病临床预防提供帮助。 方法 应用医学图像后处理软件MIMICS10.01对临床通过增强CT获得的二维医学图像数据进行处理,得到包括升主动脉、主动脉弓、降主动脉及主动脉弓上部的头臂干、左颈总动脉和左锁骨下动脉的胸主动脉的整体三维重构模型。借助软件ANSYS-CFX对主动脉弓内的血液进行血流动力学数值模拟并得到可视化结果,获取正常胸主动脉弓和患有降主动脉夹层疾病胸主动脉弓内相关血流动力学的各种参数。通过对比不同个体主动脉弓内血流动力学参数的异同,及正常胸主动脉弓和患有降主动脉夹层疾病胸主动脉弓内血流动力学参数的异同来讨论血流动力学参数对脉管疾病的影响。 结果 通过三维重构方法建立了真实的人体主动脉弓解剖系统三维几何模型,实现了基于人体主动脉弓真实解剖模型进行的血流动力学数值模拟分析。通过应用计算流体力学方法获得了主动脉弓内血流在心动周期内不同时刻的壁面压力、流线分布、壁面切应力等血流动力学参数。并且通过对不同个体的主动脉弓内的血流动力学参数的比较分析确定心脏收缩期的血管壁压力及压力变化比舒张期更大；在整个心动收缩期,主动脉外侧壁的压力明显地高于内侧壁的压力；在主动脉弓和降主动脉连接的弯曲部位处存在明显的压力变化；在主动脉弓内侧壁的壁面剪应力比主动脉弓外侧壁的壁面剪应力具有更大的量值和变化幅度；在心动收缩期主动脉弓处出现二次流现象,且在心动收缩期出现明显的漩涡现象。 结论 计算流体力学数值模拟的方法是目前研究脉管疾病血流动力学的一种可靠方法。通过三维重构方法获得了个体化仿真的包括主动脉弓及分叉的正常胸主动脉、患有降主动脉夹层的病态胸主动脉的三维模型,并确定相关关键技术方法,为进一步进行血流动力学研究分析确定基础。通过模拟对比分析,明确血管的弯曲及分叉导致局部压力变化可能与脉管疾病的形成有一定的关系。
[Abstract]:Objective to simulate the blood flow in human thoracic aorta by 3D reconstruction of medical images and computational fluid dynamics (CFD) and to obtain the corresponding hemodynamic parameters. The effects of hemodynamic parameters on aortic vascular diseases such as atherosclerosis, dissection and other diseases were investigated by analyzing the blood flow in thoracic aorta of different individuals (including normal and abnormal patients). To provide theoretical basis for the pathogenesis of various vascular diseases and to provide help for clinical prevention of vascular diseases. Methods Medical image post-processing software (MIMICS10.01) was used to process the two-dimensional medical image data obtained by enhanced CT. The ascending aorta, aortic arch, descending aorta and upper arm trunk of aortic arch were obtained, which included ascending aorta, aortic arch, descending aorta and upper part of aortic arch. Three-dimensional reconstruction model of thoracic aorta of left common carotid artery and left subclavian artery. The hemodynamic parameters of the normal aortic arch and the aortic arch with descending aortic dissection were obtained by using the software ANSYS-CFX to simulate the hemodynamics of the blood in the aortic arch and obtain the visual results. By comparing the hemodynamic parameters of different individuals in the aortic arch, The influence of hemodynamic parameters on vascular diseases was discussed by comparing the hemodynamic parameters of thoracic aortic arch with that of normal aortic arch and descending aortic dissection. Results Three-dimensional geometric model of human aortic arch anatomy system was established by three-dimensional reconstruction method, and hemodynamic numerical simulation analysis based on real anatomy model of human aortic arch was realized. The wall pressure, streamline distribution, wall shear stress and other hemodynamic parameters of the aortic arch blood flow at different times in the cardiac cycle were obtained by using computational fluid dynamics (CFD). By comparing and analyzing the hemodynamic parameters of different individuals in aortic arch, it was found that the changes of vessel wall pressure and pressure in systolic period were greater than that in diastolic phase. The pressure on the lateral wall of the aorta was significantly higher than that on the medial wall during the whole systolic period, and there was a significant change in the pressure at the bend of the aortic arch and descending aorta junction. The wall shear stress of the medial wall of the aortic arch is larger than that of the lateral wall of the aortic arch, and the secondary flow occurs at the aortic arch during the systolic period, and the vortex phenomenon appears during the contraction phase of the aortic arch, and the wall shear stress of the inner wall of the aortic arch is larger than the wall shear stress of the lateral wall of the aortic arch. Conclusion Computational fluid dynamics numerical simulation is a reliable method to study hemodynamics of vascular diseases. The three-dimensional model of the normal thoracic aorta with aortic arch and bifurcation and the diseased thoracic aorta with descending aortic dissection were obtained by three-dimensional reconstruction method, and the relevant key techniques were determined. To determine the basis for further hemodynamic analysis. By simulation and contrast analysis, it is clear that the variation of local pressure caused by the bending and bifurcation of blood vessels may be related to the formation of vascular diseases.
【学位授予单位】：中国医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R312
本文编号：2367692
[Abstract]:Objective to simulate the blood flow in human thoracic aorta by 3D reconstruction of medical images and computational fluid dynamics (CFD) and to obtain the corresponding hemodynamic parameters. The effects of hemodynamic parameters on aortic vascular diseases such as atherosclerosis, dissection and other diseases were investigated by analyzing the blood flow in thoracic aorta of different individuals (including normal and abnormal patients). To provide theoretical basis for the pathogenesis of various vascular diseases and to provide help for clinical prevention of vascular diseases. Methods Medical image post-processing software (MIMICS10.01) was used to process the two-dimensional medical image data obtained by enhanced CT. The ascending aorta, aortic arch, descending aorta and upper arm trunk of aortic arch were obtained, which included ascending aorta, aortic arch, descending aorta and upper part of aortic arch. Three-dimensional reconstruction model of thoracic aorta of left common carotid artery and left subclavian artery. The hemodynamic parameters of the normal aortic arch and the aortic arch with descending aortic dissection were obtained by using the software ANSYS-CFX to simulate the hemodynamics of the blood in the aortic arch and obtain the visual results. By comparing the hemodynamic parameters of different individuals in the aortic arch, The influence of hemodynamic parameters on vascular diseases was discussed by comparing the hemodynamic parameters of thoracic aortic arch with that of normal aortic arch and descending aortic dissection. Results Three-dimensional geometric model of human aortic arch anatomy system was established by three-dimensional reconstruction method, and hemodynamic numerical simulation analysis based on real anatomy model of human aortic arch was realized. The wall pressure, streamline distribution, wall shear stress and other hemodynamic parameters of the aortic arch blood flow at different times in the cardiac cycle were obtained by using computational fluid dynamics (CFD). By comparing and analyzing the hemodynamic parameters of different individuals in aortic arch, it was found that the changes of vessel wall pressure and pressure in systolic period were greater than that in diastolic phase. The pressure on the lateral wall of the aorta was significantly higher than that on the medial wall during the whole systolic period, and there was a significant change in the pressure at the bend of the aortic arch and descending aorta junction. The wall shear stress of the medial wall of the aortic arch is larger than that of the lateral wall of the aortic arch, and the secondary flow occurs at the aortic arch during the systolic period, and the vortex phenomenon appears during the contraction phase of the aortic arch, and the wall shear stress of the inner wall of the aortic arch is larger than the wall shear stress of the lateral wall of the aortic arch. Conclusion Computational fluid dynamics numerical simulation is a reliable method to study hemodynamics of vascular diseases. The three-dimensional model of the normal thoracic aorta with aortic arch and bifurcation and the diseased thoracic aorta with descending aortic dissection were obtained by three-dimensional reconstruction method, and the relevant key techniques were determined. To determine the basis for further hemodynamic analysis. By simulation and contrast analysis, it is clear that the variation of local pressure caused by the bending and bifurcation of blood vessels may be related to the formation of vascular diseases.
【学位授予单位】：中国医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R312
【引证文献】
相关博士学位论文 前1条
1 肖汉光;心血管系统的电网络建模及动脉硬化与狭窄诊断研究[D];重庆大学;2012年
相关硕士学位论文 前2条
1 初博;搭桥术治疗DeBakey Ⅲ型主动脉夹层的流固耦合数值模拟研究[D];北京工业大学;2011年
2 赵璐;不锈钢冠脉支架结构设计及动态应力数值模拟[D];哈尔滨工程大学;2012年
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