培养大脑皮层感觉运动神经元活动依赖突触可塑性机制的研究

发布时间：2020-12-15 01:11

　　In order to explore the evidence of transient neuronal plasticity observed in human sensorimotor cortex during development of learning, the mechanisms of activity-dependent synaptic modification in cultured cortical sensorimotor neurons in rats were studied. Long-term potentiation （LTP） is an activity-dependent strengthening of synaptic efficacy that is considered to be one of indexes of learning and memory in the present study. Voltage pulse, as a model of repetitive electrical stimulation, was... 

【文章来源】：中国人民解放军军事科学院北京市

【文章页数】：75 页

【学位级别】：博士

【文章目录】：
Abstract
Introduction
Experimental procedures
    Ⅰ． Cell culture
    Ⅱ． Solutions
    Ⅲ． Electrophysiology
    Ⅳ． Data analysis and statistics
Results
    Ⅰ． Cortical sensorimotor neurons in VLD cultures
    Ⅱ． Voltage-gated ionic channels
    Ⅲ． Spontaneous neuronal activity of cortical sensorimotor neuron
    Ⅳ． Properties of spontaneous EPSCs of cortical sensorimotor neurons
    Ⅴ． Voltage-pulses potentiate spontaneouse neuronal activity
    Ⅵ． NMDA application potentiates synaptic transmission
Discussion
Summary
References
Acknowledgement
Abbreviations
List of publications


【参考文献】：
期刊论文
[1]乙酰胆碱对培养大鼠皮层神经元兴奋性及抑制性突触电流的相反作用[J]. 刘青松,何湘平,刘传缋.  生理学报. 1996(04)



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