应用于膀胱功能重建的多通道骶神经前根刺激系统设计与实验研究

发布时间：2018-03-01 08:24

本文关键词： 膀胱功能重建骶神经前根刺激介质实验动物实验　出处：《中国生物医学工程学报》2017年02期 　论文类型：期刊论文

【摘要】：设计一种用于膀胱功能重建的多通道骶神经前根刺激系统。首先根据骶神经前根刺激(SARS)原理,确定系统功能指标与设计方案。完成各个模块软硬件设计与系统集成后,进行空气、生理盐水以及猪肉组织3种介质中的测试以及动物实验。在介质实验中,将发射和接收模块放在模拟人体环境的介质之中,测量各种空间条件下接收模块所接收到信号强度。结果表明,该系统可以在3种条件下实现信号的无线跨皮传输。动物实验中,发射模块放在猪肉表面,接收模块包埋在猪肉之中,通过钩状电极将接收到的刺激信号施加到蟾蜍的坐骨神经上。对6只蟾蜍所做的实验表明,系统可以在体内模块包埋深度达4 cm且容许一定位置容限的情况下,刺激蟾蜍左、右腿的坐骨神经分别产生明显伸腿动作,证明系统的可行性。系统的设计与实验研究为研发具有自主知识产权的可用于临床的SARS装置打下了基础。
[Abstract]:A multi-channel sacral nerve anterior root stimulation system was designed for bladder function reconstruction. Firstly, according to the principle of sacral nerve anterior root stimulation (SARSs), the function index and design scheme of the system were determined. In air, saline and pork tissue testing and animal experiments. In the medium experiment, the emitter and receiver modules are placed in the medium that simulates the human environment. The results show that the system can realize wireless transdermal transmission of signals under three conditions. In animal experiments, the emitter module is placed on the pork surface. The receiving module was embedded in the pork, and the received stimulation signal was applied to the sciatic nerve of the toad by hook electrode. The system can stimulate the sciatic nerve of the left and right legs of toad by stimulating the sciatic nerve of the left and right legs of the toad with a depth of 4 cm and a certain position tolerance. The feasibility of the system is proved. The design and experimental research of the system lay a foundation for the development of clinical SARS devices with independent intellectual property rights.
【作者单位】：东南大学生物电子学国家重点实验室;南通大学神经再生协同创新中心;东南大学射频与光电集成电路研究所;
【分类号】：R651.2

【相似文献】