不同分子分型乳腺癌术后复发转移风险及其时间分布规律

发布时间：2018-03-01 18:20

本文关键词： 乳腺癌分子分型复发转移风险时间分布　出处：《中国卫生统计》2017年01期 　论文类型：期刊论文

【摘要】：目的探讨不同分子分型乳腺癌术后复发转移风险及其时间分布规律。方法收集345名2004年1月1日-2012年12月31日于厦门市某三甲医院手术治疗的女性乳腺癌患者资料,根据免疫组化结果将乳腺癌分成Luminal A、Luminal B、BCL和Her-2/neu 4种分子分型,随访其复发转移情况,末次随访时间为2014年9月30日。用寿命表法估计不同分子分型乳腺癌患者未复发转移生存率和复发转移风险,同时用log-rank检验进行组间比较,进一步地,采用Cox回归分析其复发转移的影响因素。结果术后总复发转移率为36.5%,Her-2/neu、Luminal B、Luminal A和BCL型患者的复发转移率依次为47.89%、35.26%、32.10%和29.73%。单因素和多因素结果均表明,分子分型影响患者术后复发转移(P0.05),Her-2/neu型患者的术后复发转移风险最高,是Luminal A的2.27倍(P0.05)。BCL型的术后复发转移风险呈三峰分布,其余均为双峰型;Her-2/neu和BCL型首次高峰出现在术后第1年,Luminal A和Luminal B型则为第2年;4种分型的另一高峰为术后第5年;BCL型在术后第3年还出现一次小高峰。结论分子分型对乳腺癌术后复发转移具有预测价值,且不同分子分型患者术后复发转移风险不同,其时间分布呈一定规律性。
[Abstract]:Objective to investigate the risk of postoperative recurrence and metastasis of breast cancer with different molecular types and its temporal distribution. Methods data of 345 female breast cancer patients who underwent surgical treatment from January 1st 2004 to December 31st 2012 in a third Class A Hospital in Xiamen City were collected. According to the immunohistochemical results, breast cancer was divided into four molecular types: Luminal Luminal BCL and Her-2/neu. The recurrence and metastasis of breast cancer were followed up. The last follow-up period was September 30th 2014. The life table method was used to estimate the survival rate and the risk of recurrence and metastasis in patients with different molecular types of breast cancer. At the same time, the log-rank test was used to compare the survival rate and the risk of recurrence and metastasis among groups. Results the total recurrence and metastasis rates of patients with Her-2 / N Luminal Luminal A and BCL were 47.8935. 26.2% and 29.73%, respectively. The results of single factor and multivariate analysis showed that the recurrence and metastasis rates of the patients with recurrence and metastasis were 36.5% and 29.73%, respectively. The risk of postoperative recurrence and metastasis was the highest in patients with P0.05% Her-2 / neu type and 2.27 times of Luminal A, and the risk of recurrence and metastasis of P0.05. BCL type was three peaks. The other two peaks of Her-2 / neu and BCL type appeared in the first year after operation. The other peak was the second year after operation. The second peak was the fifth year after operation. There was also a small peak in the third year after operation. Classification has predictive value for recurrence and metastasis of breast cancer after operation. The risk of recurrence and metastasis was different in patients with different molecular typing, and the time distribution was regular.
【作者单位】：厦门大学公共卫生学院;卫生技术评估福建省高校重点实验室;厦门大学附属第一医院肿瘤科;
【基金】：厦门市科技计划项目(3502Z20143006)
【分类号】：R737.9

【相似文献】