置入碳纤维增强聚醚醚酮股骨头假体稳定性的生物力学分析

发布时间：2018-03-13 15:12

本文选题：钴铬钼合金　切入点：生物假体　出处：《中国组织工程研究》2017年15期 　论文类型：期刊论文

【摘要】：背景:在关节置换领域里,金属合金材料始终处于主导地位,但这种材料的最大缺陷是弹性模量高,由此产生应力遮挡,进而引起骨吸收、骨萎缩甚至假体松动等一系列并发症。碳纤维增强聚醚醚酮复合材料是各向异性材料,可以达到低弹高强,应用于制备人工假体有许多优势。目的:探讨碳纤维增强聚醚醚酮复合材料的血液相容性,并比较了碳纤维增强聚醚醚酮复合材料股骨头假体和钴铬钼合金股骨头假体置换后的生物力学特性。方法:(1)以溶血实验评价碳纤维增强聚醚醚酮复合材料的血液相容性;(2)收集8对新鲜成人尸体股骨标本,随机分为碳纤维增强聚醚醚酮假体组和钴铬钼合金假体组进行相应假体置换,测量加载200,400,600,800,1 000 N负荷下假体与骨之间的微动量,并检测假体置换后的抗扭转强度。结果与结论:(1)以碳纤维增强聚醚醚酮复合材料的溶血率为3.23%5%,符合国家医疗器械生物学评价标准;(2)2组假体远端微动均明显小于近端(P0.05);不同负荷下钴铬钼合金假体组远端、近端的微动量均显著大于碳纤维增强聚醚醚酮假体组(P0.05);(3)碳纤维增强聚醚醚酮假体组不同负荷下的载荷-扭角均显著小于钴铬钼合金假体组(P0.05),抗扭刚度均显著大于钴铬钼合金假体组(P0.05);(4)结果说明碳纤维增强聚醚醚酮复合材料血液相容性较好,具有较好的稳定性,可用于假体置换。
[Abstract]:Background: in the field of joint replacement, metal alloy materials are always in the dominant position, but the biggest defect of this material is the high modulus of elasticity, which results in stress occlusion, which leads to bone resorption. Carbon fiber reinforced polyether ether ketone composite is an anisotropic material that can achieve low elasticity and high strength. There are many advantages in the preparation of artificial prostheses. Objective: to study the blood compatibility of carbon fiber reinforced polyether ether ketone composites. The biomechanical properties of carbon fiber reinforced poly (ether ether ketone) composite femoral head prosthesis and cobalt-chromium-molybdenum alloy femoral head prosthesis were compared. Methods Hemolysis experiment was used to evaluate the blood of carbon fiber reinforced polyether ether ketone composite. Eight pairs of fresh adult cadaveric femur specimens were collected. Carbon fiber reinforced polyether ether ketone prosthesis group and cobalt chromium-molybdenum alloy prosthesis group were randomly divided into two groups. Results and conclusion the hemolysis rate of carbon fiber reinforced polyether ether ketone composite material is 3.235, which conforms to the national biological evaluation standard of medical devices. The distal fretting of the two groups is obviously smaller than that of the near. P0.05N; distal end of cobalt-chromium-molybdenum alloy prosthesis group under different loads, The micromomentum at the proximal end was significantly higher than that in the carbon fiber reinforced polyether ether ketone prosthesis group (P 0.05). The load-torsion angle of the carbon fiber reinforced polyether ether ketone prosthesis group was significantly lower than that of the cobalt chromium molybdenum alloy prosthesis group (P 0.05), and the torsional stiffness was significantly higher than that of the Co Cr Mo alloy prosthesis group. The results showed that carbon fiber reinforced polyether ether ketone composite had better blood compatibility. It has good stability and can be used in prosthesis replacement.
【作者单位】：海南医学院第一附属医院;
【基金】：海南省自然科学基金资助项目(814357)~~
【分类号】：R318.08;R687.4

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