NLR与PLR对成人急性阑尾炎临床病理分型诊断价值的研究

发布时间：2018-05-13 05:35

本文选题：急性阑尾炎 + 中性粒细胞与淋巴细胞比值　；参考：《延边大学》2016年硕士论文

【摘要】：目的探讨中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio, NLR)、血小板与淋巴细胞比值(platelet to lymphocyte ratio, PLR)与成人急性阑尾炎(acute appendicitis, AA)I临床病理分型的关系和临床意义。方法收集2012年1月到2015年8月间在我院普外科行阑尾切除并术后病理证实为AA的成人患者353例及同期健康成人体检者50例,根据临床病理分型将AA患者分为急性单纯性阑尾炎组(A1组)、急性蜂窝织性阑尾炎组(A2组)、急性坏疽性阑尾炎组(A3组)；健康成人体检者(B组),采集各组患者术前血常规各项指标,计算NLR和PLR比值,比较分析各组NLR和PLR与AA病理分型的关系。结果1.A组患者NLR和PLR明显高于B组(P0.0001)；A组内NLR及PLR的数据差异有统计学意义(P0.0001)；A1-A3组间NLR差异有统计学意义(P0.0001)；PLR在A1和A3组差异有统计学意义(P0.0001),A1和A2组、A2和A3组差异无统计学意义(均P0.017)。2.A1-A3组NLR的ROC曲线下面积各为0.707,0.952和0.972；PLR的ROC曲线下面积各为0.737,0.791和0.829；与对照组比较均有显著性差异(均P0.0001)。3.A1-A3各组NLR的ROC曲线cut-off值各为1.63、4.97和5.89,灵敏度52.08%、89.51%、96.88%,特异性68.55%、98%、98%；(均P0.0001)。A1-A3各组PLR的ROC曲线cut-off值各为81.63、131.78和184.54,灵敏度41.35%、53.23%、60.42%,特异性均100%；(均P0.00015)。结论术前NLR和PLR可作为AA临床病理分型的指标；NLR较PLR对AA具有更好的诊断敏感性。
[Abstract]:Objective to investigate the relationship between neutrophil to lymphocyte ratio, NLRN, platelet-lymphocyte ratio to lymphocyte ratio, PLR) and acute appendicitis (AA)I) in adults with acute appendicitis (AA)I) and its clinical significance. Methods from January 2012 to August 2015, 353 adult patients underwent appendectomy and confirmed AA by pathology in our hospital and 50 healthy adults were examined in the same period. According to the clinicopathological classification, AA patients were divided into acute simple appendicitis group A 1 group, acute cellulocytic appendicitis group A 2 group, acute gangrene appendicitis group A 3 group, healthy adults group B group, blood routine examination of each group before operation. The ratio of NLR and PLR was calculated, and the relationship between NLR and PLR and the pathological classification of AA was compared and analyzed. Results 1. NLR and PLR in group A were significantly higher than those in group B (P 0.0001A). There was significant difference in NLR and PLR between group A and group A (P 0.0001A 1-A 3). There was significant difference between group A and group A (P 0.0001). There was no significant difference between group A (P 0.0001A 1) and group A (A 2) and group A 3 (P 0.0001A 3). (the area under ROC curve of NLR in P0.017).2.A1-A3 group was 0.7070.952 and the area under ROC curve of 0.972L PLR was 0.7370.791 and 0.829 respectively, and there was significant difference compared with control group (cut-off value of ROC curve of NLR in all P0.0001).3.A1-A3 groups were 1.634.97 and 5.89, sensitivity 52.0889.51d) and specificity were 96.888.The area under ROC curve of NLR in P0.017).2.A1-A3 group was 0.7070.9952 and 0.972plr was 0.737-0.791 and 0.829, respectively, and the cut-off value of ROC curve of P0.0001).3.A1-A3 group was 1.634.97 and 5.89 respectively. The ROC curve cut-off values of PLR in all P0.0001).A1-A3 groups were 81.63131.78 and 184.54, respectively. The sensitivity of 41.35 and 53.23was 60.42, and the specificity was 100 (P 0.00015). Conclusion preoperative NLR and PLR are more sensitive than PLR in the diagnosis of AA.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R656.8

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