普瑞巴林联合依托考昔治疗膝骨关节炎疼痛的临床疗效

发布时间：2018-06-27 05:14

本文选题：骨关节炎 + 膝　；参考：《中国全科医学》2017年S1期

【摘要】：目的探讨普瑞巴林联合依托考昔治疗膝关节骨关节炎疼痛的临床疗效。方法选取商丘市第一人民医院2014年2月—2016年2月收治的膝骨关节炎疼痛患者80例,按照随机数字表法将患者分为观察组和对照组,各40例。观察组患者予以普瑞巴林胶囊与依托考昔片治疗,对照组患者予以依托考昔片治疗,两组患者均连续治疗8周。比较两组患者治疗前、治疗1周、4周及8周膝关节视觉模拟评分量表(VAS)评分、日常活动程度量表(WOMAC)评分,治疗前后焦虑自评量表(SAS)评分、匹兹堡睡眠质量指数(PSQI)评分、肝肾功能指标[谷丙转氨酶(ALT),谷草转氨酶(AST),血肌酐(Cr)、尿素氮(BUN)],观察两组患者不良反应发生情况。结果治疗前两组患者膝关节VAS评分、WOMAC评分比较,差异无统计学意义(P0.05);治疗1周、4周及8周观察组患者膝关节VAS评分、WOMAC评分低于对照组(P0.05);两组患者治疗1周、4周及8周膝关节VAS评分、WOMAC评分低于治疗前(P0.05)。治疗前两组患者SAS和PSQI评分比较,差异无统计学意义(P0.05);治疗后观察组患者SAS和PSQI评分低于对照组(P0.05);两组患者治疗后SAS评分低于治疗前,观察组患者治疗后PSQI评分低于治疗前(P0.05)。治疗前后两组患者ALT、AST、Cr和BUN水平比较,差异无统计学意义(P0.05)。观察组不良反应发生率低于对照组(P0.05)。结论瑞普巴林联合依托考昔治疗膝关节骨关节炎疼痛的临床疗效确切,其镇痛效果好,可有效改善患者膝关节功能、焦虑程度和睡眠质量,安全性高。
[Abstract]:Objective to investigate the clinical effect of Premarin combined with oxicoxib in the treatment of knee osteoarthritis pain. Methods Eighty patients with knee osteoarthritis pain treated in the first people's Hospital of Shangqiu from February 2014 to February 2016 were randomly divided into observation group and control group with 40 cases each. The patients in the observation group were treated with Prebin capsule and etacoxib, while the patients in the control group were treated with the tablet for 8 weeks. The scores of visual analogue scale (VAS), daily activity scale (WOMAC), self rating anxiety scale (SAS) and Pittsburgh Sleep quality Index (PSQI) before and after treatment were compared between the two groups. The indexes of liver and kidney function [alt, AST, Cr, bun] were observed. Results VAS score and WOMAC score of knee joint were compared between the two groups before treatment. There was no significant difference between the two groups (P0.05); the VAS score of the knee joint in the observation group was lower than that in the control group at 1 week and 8 weeks (P0.05); the VAS score of the knee joint in the two groups was lower than that before the treatment (P0.05). There was no significant difference in SAS and PSQI scores between the two groups before treatment (P0.05); after treatment, the SAS and PSQI scores in the observation group were lower than those in the control group (P0.05); the SAS scores after treatment in the two groups were lower than those before treatment, and the PSQI scores in the observation group after treatment were lower than those before treatment (P0.05). Before and after treatment, there was no significant difference in alt ASTN Cr and bun levels between the two groups (P0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P0.05). Conclusion the clinical curative effect of the treatment of knee osteoarthritis pain with the combination of ripraxine and coxim is definite, and its analgesic effect is good. It can effectively improve the knee joint function, anxiety degree and sleep quality of the patients, and has high safety.
【作者单位】：河南省商丘市第一人民医院;
【分类号】：R684.3

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