右美托咪定用于体外循环心内直视手术对患者术后镇静的效果

发布时间：2018-11-01 15:29

【摘要】：目的:探讨右美托咪定用于体外循环心内直视手术后患者的ICU镇静效果和安全性。方法:选取体外循环心内直视手术后转入ICU行机械通气的患者90例,将患者随机分为右美托咪定组(D组)45例和丙泊酚组(P组)45例,分别接受右美托咪定和丙泊酚静脉持续镇静。观察并记录两组患者镇静评分、机械通气时间、舒芬太尼24 h用量、ICU住院时间等参数,以及低血压、谵妄、心动过缓等不良反应发生率。结果:两组患者镇静满意度均80%,差异无统计学意义(P0.05);D组患者机械通气时间明显短于P组(P0.05);D组舒芬太尼24 h用量及ICU住院时间均少于P组(P0.01)。两组在镇静治疗过程中低血压发生率D组低于P组(P0.05),心动过缓及谵妄发生率差异无统计学意义(P0.05)。结论:右美托咪定用于体外循环心内直视手术患者术后镇静安全有效,且有助于促进患者术后恢复。
[Abstract]:Objective: to investigate the sedation effect and safety of dexmetidine in patients undergoing open heart surgery under cardiopulmonary bypass (CPB). Methods: ninety patients undergoing open heart surgery under cardiopulmonary bypass (CPB) were randomly divided into two groups: dexmetomidine group (group D, n = 45) and propofol group (group P, n = 45). Intravenous sedation was performed with dexmetomidine and propofol, respectively. Sedation score, mechanical ventilation time, 24 h dosage of sufentanil, ICU hospitalization time, and the incidence of adverse reactions such as hypotension, delirium and bradycardia were observed and recorded. Results: there was no significant difference in sedation satisfaction between the two groups (P0.05). The time of mechanical ventilation in); D group was significantly shorter than that in P group (P0.05). The dosage of sufentanil and the hospitalization time of ICU in group D were less than those in group P (P0.01). The incidence of hypotension in group D was lower than that in group P (P0.05), but there was no significant difference in the incidence of bradycardia and delirium between the two groups (P0.05). Conclusion: dexmetomidine is safe and effective for postoperative sedation and recovery of patients undergoing open heart surgery under cardiopulmonary bypass.
【作者单位】：广东省人民医院(广东省医学科学院) 广东省心血管病研究所麻醉科;广东省人民医院(广东省医学科学院) 广东省心血管病研究所SICU;
【基金】：广东省卫生厅基金资助课题(编号:A2016051)
【分类号】：R614

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