帕瑞昔布对骨关节病髋关节置换术患者术后炎症细胞因子及认知功能的影响

发布时间：2018-11-18 09:49

【摘要】：目的探讨帕瑞昔布对骨关节病髋关节置换术患者术后炎症细胞因子及认知功能的影响。方法抽取2014年6月~2016年3月我院接收的符合研究选取标准的74例择期行髋关节置换术骨关节病患者,根据入院先后顺序不同分为对照组(n=37)与研究组(n=37)。研究组联合舒芬太尼自控镇痛及帕瑞昔布,对照组仅采用舒芬太尼自控镇痛。对比术前及术后不同时间(术后1h、6h、12h)两组炎症细胞因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、术前及术后不同时间(术后第1d、3d、7d)两组认知功能评分及术前与术后不同时间(术后1h、6h、12h)两组肾上腺素及皮质醇水平变化情况。结果术前两组IL-6、TNF-α水平无明显差异(P0.05),研究组术后各时期IL-6水平、术后12h TNF-α水平低于对照组,差异有统计学意义(P0.05);术前两组肾上腺素及皮质醇水平无明显差异(P0.05),研究组术后12h肾上腺素及6h、12h皮质醇水平优于对照组,差异有统计学意义(P0.05);术前两组肾上腺素及皮质醇水平无明显差异(P0.05),研究组术后12h肾上腺素及6h、12h皮质醇水平优于对照组,差异有统计学意义(P0.05)。结论采用帕瑞昔布可有效改善骨关节病髋关节置换术患者炎症细胞因子及应激激素水平,保护其认知功能,值得推广。
[Abstract]:Objective to investigate the effect of paroxib on inflammatory cytokines and cognitive function in patients with osteoarthropathy after hip arthroplasty. Methods from June 2014 to March 2016, 74 patients with osteoarthropathy undergoing hip arthroplasty were selected and divided into control group (n = 37) and study group (n = 37) according to the order of admission. The study group combined with sufentanil and paroxib, the control group only received sufentanil. The levels of inflammatory cytokines [interleukin-6 (IL-6), tumor necrosis factor- 伪 (TNF- 伪)] at different time after operation (1h, 6h and 12h after operation) were compared, and the levels of inflammatory cytokines [interleukin-6 (IL-6), tumor necrosis factor- 伪 (TNF- 伪)] before and after operation were compared. The changes of epinephrine and cortisol levels at different time before and after operation (1 h, 6 h and 12 h after operation) were observed in both groups on the 7th day. Results there was no significant difference in the level of IL-6,TNF- 伪 between the two groups before operation (P0.05). The level of IL-6 in the study group was lower than that in the control group at 12 hours after operation (P0.05). There was no significant difference in the levels of adrenaline and cortisol between the two groups before operation (P0.05). The levels of epinephrine and cortisol in the study group were significantly higher than those in the control group at 12 hours and 6 hours after operation (P0.05). There was no significant difference in the levels of adrenaline and cortisol between the two groups before operation (P0.05). The levels of epinephrine and cortisol in the study group were better than those in the control group at 12 hours and 6 hours after operation (P0.05). Conclusion Paroxib can effectively improve the levels of inflammatory cytokines and stress hormones in hip arthroplasty patients with osteoarthritis and protect their cognitive function.
【作者单位】：首都医科大学附属北京世纪坛医院麻醉科;
【分类号】：R614

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