左氧氟沙星联合聚维酮碘对开腹手术患者切口感染的影响

发布时间：2018-12-08 12:10

【摘要】：目的探讨左氧氟沙星联合聚维酮碘对开腹手术患者切口感染的影响,为切口感染的临床预防提供科学的参考依据。方法选取2014年8月-2016年7月在医院接受开腹手术的患者300例,分为观察组(左氧氟沙星+聚维酮碘)和对照组(头孢曲松+生理盐水),比较两组患者的切口愈合程度、感染率、愈合拆线时间、住院时间、白细胞计数及C反应蛋白水平。结果观察组切口愈合程度:甲级143例95.33%,乙级3例2.00%,丙级4例2.67%;对照组切口愈合程度:甲级126例84.00%,乙级15例10.00%,丙级9例6.00%;观察组切口感染2例,感染率为1.33%,分离病原菌2株,其中金黄色葡萄球菌1株,大肠埃希菌1株;对照组切口感染19例,感染率为12.67%,共分离病原菌19株,其中金黄色葡萄球菌7株,大肠埃希菌5株,肺炎克雷伯菌2株,铜绿假单胞菌2株,其他3株;观察组患者愈合拆线时间和住院时间均明显低于对照组,差异有统计学意义(P0.05);术前,两组患者白细胞计数和C反应蛋白差异无统计学意义;术后,观察组白细胞计数和C反应蛋白均明显低于对照组,差异有统计学意义(P0.05)。结论左氧氟沙星联合聚维酮碘在开腹手术患者切口感染的防控方面具有明显优势,能够有效促进切口愈合,降低切口感染风险,值得临床推广。
[Abstract]:Objective to investigate the effect of levofloxacin combined with povidone iodine on incision infection in patients undergoing open surgery, and to provide scientific reference for clinical prevention of incision infection. Methods 300 patients undergoing open surgery in hospital from August 2014 to July 2016 were divided into observation group (levofloxacin povidone iodine) and control group (ceftriaxone saline). Infection rate, healing time, hospitalization time, leukocyte count and C reactive protein level. Results in the observation group, the wound healing degree was 95.33 in 143 cases, 2.00 in grade B and 2.67 in grade C, while in the control group, it was 84.00 in 126 cases, 10.00 in 15, 6.00 in 9. In the observation group, there were 2 cases of incision infection, the infection rate was 1.33%, 2 strains of pathogenic bacteria were isolated, including 1 strain of Staphylococcus aureus and 1 strain of Escherichia coli. In the control group, 19 cases were infected with incision infection, the infection rate was 12.67%. A total of 19 strains of pathogenic bacteria were isolated, including 7 strains of Staphylococcus aureus, 5 strains of Escherichia coli, 2 strains of Klebsiella pneumoniae, 2 strains of Pseudomonas aeruginosa and 3 strains of others. The healing time and hospitalization time of the patients in the observation group were significantly lower than those in the control group (P0.05), the white blood cell count and C-reactive protein were not significantly different between the two groups before operation. After operation, the white blood cell count and C-reactive protein in the observation group were significantly lower than those in the control group (P0.05). Conclusion levofloxacin combined with povidone iodine has obvious advantages in prevention and control of incision infection in patients undergoing open surgery. It can effectively promote wound healing and reduce the risk of incision infection.
【作者单位】：福建医科大学附属第二医院手术室;
【基金】：福建省泉州市科技计划项目(2012Z45)
【分类号】：R619.3

【相似文献】