轻度认知功能障碍老年患者腰椎减压植骨融合术七氟醚复合丙泊酚的适宜配伍剂量

发布时间：2019-01-18 10:35

【摘要】：目的探讨轻度认知功能障碍(mild cognitive impairment,MCI)老年患者腰椎减压植骨融合术七氟醚复合丙泊酚的适宜配伍剂量,以保护其认知功能。方法选择择期行腰椎减压植骨融合术的患者80例,男41例,女39例,年龄65~75岁,BMI 17~26kg/m~2,ASAⅠ或Ⅱ级,术前通过蒙特利尔量表(Montreal cognitive assessment,MoCA)、简易智力状态量表(mini mental state examination,MMSE)、痴呆量表(dementia scale,CDR)和日常生活能力量表(daily living ability scale,ADL)评估认定为轻度认知功能障碍患者。采用随机数字表法将患者分为四组:TCI丙泊酚2.0~2.5μg/ml组(P组)、TCI丙泊酚1.2μg/ml+七氟醚0.6 MAC组(PS1组)、TCI丙泊酚0.6μg/ml+七氟醚0.9MAC组(PS2组)和1.0~1.5MAC七氟醚组(S组)。在术前1d(T_0)、术后完全苏醒(T_1)、3d(T_2)、7d(T_3)采用MMSE和MoCA量表评估患者认知功能,采用ELISA法测定血浆载脂蛋白J(apolipoprotein J,ApoJ)浓度。结果与T_0时比较,T_1时四组MMSE和MoCA评分明显降低(P0.05),T_2时S组MMSE和MoCA评分明显降低(P0.05);与T_1时比较,T_2、T_3时四组MMSE和MoCA评分明显升高(P0.05)。T_1~T_3时S组MMSE评分明显低于P组、PS1组和PS2组(P0.05);T_2、T_3时S组MoCA评分明显低于P组、PS1组和PS2组(P0.05)。与T_0时比较,T_1时四组血浆ApoJ浓度明显升高(P0.05);与T_1时比较,T_2、T_3时四组血浆ApoJ浓度明显降低(P0.05)。T_1~T_3时S组和PS2组血浆ApoJ浓度明显高于PS1组(P0.05)。结论 MCI老年患者行腰椎减压植骨融合术时TCI丙泊酚1.2μg/ml复合七氟醚0.6MAC对老年患者认知功能影响较小,血浆ApoJ浓度较低。
[Abstract]:Objective to investigate the appropriate dosage of sevoflurane combined with propofol in lumbar decompression and bone graft fusion in elderly patients with mild cognitive impairment (mild cognitive impairment,MCI) in order to protect their cognitive function. Methods A total of 80 patients (41 males and 39 females, aged 65 to 75 years) undergoing lumbar decompression and bone graft fusion were enrolled in this study. The patients were divided into two groups: BMI 17 ~ 26kg 路m ~ (-1) / m ~ (2) ASA 鈪，

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