Methylprednisolone promotes recovery of neurological functio

发布时间：2021-10-18 18:29

　　Some studies have indicated that the Wnt/β-catenin signaling pathway is activated following spinal cord injury,and expression levels of specific proteins,including low-density lipoprotein receptor related protein-6 phosphorylation,β-catenin,and glycogen synthase kinase-3β,are significantly altered.We hypothesized that methylprednisolone treatment contributes to functional recovery after spinal cord injury by inhibiting apoptosis and activating the Wnt/β-catenin signaling pathway.In the current s... 

【文章来源】：Neural Regeneration Research. 2016,11(11)SCICSCD

【文章页数】：8 页

【文章目录】：
Graphical Abstract
Introduction
Materials and Methods
    Animals
    Rat SCI model and MP administration
    Analysis of locomotor activity in the SCI rat model
    Tissue preparation
    Nissl staining of spinal cord tissue following SCI
    Western blot assay of spinal cord tissue following SCI
    TUNEL assay of spinal cord tissue following SCI
    Immunofl uorescence staining of spinal cord tissue following SCI
    Statistical analysis
Results
    MP promoted locomotor functional recovery aft er SCI
    MP treatment improved pathological recovery post-SCI
    MP activated Wnt/β-catenin signaling pathway at er SCI
    Cell apoptosis inhibited by MP following SCI
Discussion



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