射血分数下降的心力衰竭患者血浆NPY、hs-CRP与LVEF的相关性研究

发布时间：2017-12-27 04:07

本文关键词：射血分数下降的心力衰竭患者血浆NPY、hs-CRP与LVEF的相关性研究　出处：《蚌埠医学院》2015年硕士论文　论文类型：学位论文

【摘要】：目的:1.了解神经肽Y(Neuropeptide Y,NPY)及超敏C反应蛋白(High sensitivity C-reaction protein,hs-CRP)在射血分数下降的心力衰竭(Heart failure with reduced ejection fraction,HFREF)患者体内血浆浓度的变化;2.探讨血浆神经肽Y、超敏C-反应蛋白与射血分数下降的心力衰竭患者左室射血分数(Left ventricular ejection fractions,LVEF)的相关性。方法:1.选取50例射血分数下降的心力衰竭患者纳入实验组,于入院次日清晨空腹时抽取肘静脉血用于测定血浆神经肽Y和超敏C-反应蛋白的水平,并于同日行心脏彩色超声检查测定左室射血分数;在治疗7日后,再次抽取肘静脉血测定血浆神经肽Y和超敏C-反应蛋白水平。2.纳入同期体检正常的50人作为健康对照组。结果:1.实验组治疗前的血浆神经肽Y和超敏C-反应蛋白水平较对照组显著升高(P0.05),且心功能越差,二者的浓度越高。2.实验组血浆神经肽Y和超敏C-反应蛋白水平在治疗后较治疗前明显下降(P0.05)。3.左室射血分数在实验组较对照组有显著下降(P0.05)。4.射血分数下降的心力衰竭患者血浆神经肽Y和超敏C-反应蛋白水平与左室射血分数呈负相关(P0.05)。结论:1.神经肽Y和超敏C反应蛋白参与了射血分数下降的心力衰竭发生发展过程,二者在心衰患者体内浓度越高,则心功能越差。2.神经肽Y和超敏C反应蛋白与左室射血分数具有一定的相关性,随着二者水平的升高,心室排血功能减弱。3.联合检测神经肽Y和超敏C-反应蛋白能够提高评估心衰患者心功能及病情状况的准确性。
[Abstract]:Objective: 1. to investigate the neuropeptide Y (Neuropeptide Y NPY) and high sensitive C reactive protein (High sensitivity C-reaction protein, hs-CRP) in heart failure decreased ejection fraction (Heart failure with reduced ejection fraction, HFREF) concentrations in the patients; 2. to investigate the plasma neuropeptide Y, high-sensitivity C-reactive protein and shot down C- the left ventricular ejection fraction in patients with heart failure ejection fraction (Left ventricular ejection fractions, LVEF) correlation. Methods: 1. selected 50 cases were decreased ejection fraction in patients with congestive heart failure in the experimental group, to the hospital the next morning when fasting cubital venous blood samples for determination of plasma neuropeptide Y and hypersensitive C- reactive protein level, and on the same day for echocardiography measured left ventricular ejection fraction; in 7 days after treatment, RE Extraction venous blood determination of plasma neuropeptide Y and high sensitive C- reactive protein level. 2. as a healthy control group, 50 people with normal physical examination were included in the same period. Results: 1.. The plasma levels of neuropeptide Y and high sensitivity C- reactive protein in the experimental group were significantly higher than those in the control group before treatment (P0.05), and the worse the cardiac function, the higher the two concentration. 2. the level of plasma neuropeptide Y and hypersensitive C- reactive protein in the experimental group was significantly lower than that before treatment (P0.05). 3. the left ventricular ejection fraction in the experimental group was significantly lower than that in the control group (P0.05). 4. the levels of plasma neuropeptide Y and hypersensitive C- reactive protein in patients with decreased ejection fraction were negatively correlated with left ventricular ejection fraction (P0.05). Conclusion: 1., neuropeptide Y and high sensitivity C reactive protein play a role in the development of heart failure with decreased ejection fraction. The higher the concentration of two in patients with heart failure, the worse the cardiac function. 2. neuropeptide Y and hypersensitive C reactive protein have a certain correlation with left ventricular ejection fraction. With the increase of the level of the two, the function of ventricular ejection is weakened. 3. the combined detection of neuropeptide Y and hypersensitive C- reactive protein can improve the accuracy of the assessment of cardiac function and condition in patients with heart failure.
【学位授予单位】：蚌埠医学院
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R541.6

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