大株红景天对稳定性心绞痛临床疗效及LP-PLA2、hs-CRP影响的研究

发布时间：2018-01-01 10:10

本文关键词：大株红景天对稳定性心绞痛临床疗效及LP-PLA2、hs-CRP影响的研究　出处：《南京中医药大学》2016年硕士论文　论文类型：学位论文

【摘要】：目的：观察大株红景天注射液对稳定性心绞痛患者治疗效果及其对脂蛋白相关性磷脂酶A2 (lipoprotein correlation phospholipase A2, Lp-PLA2)及超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)的影响,探讨大株红景天对稳定性心绞痛的治疗作用及其作用机制是否与炎症因子有关。方法：将80例符合纳入标准的患者随机分为治疗组与对照组,每组40例。对照组给与冠心病常规治疗。治疗组40例,在常规治疗基础上给与10m1大株红景天注射液以5%葡萄糖注射液250ml稀释后静滴,1次／天,疗程14天；观察对比患者治疗前后中医证候积分、心绞痛症状、心电图情况、Lp-PLA2及hs-CRP、血脂、肝肾功能的变化,Lp-PLA2及hs-CRP分别采用散色比浊法与免疫比浊法测定。结果：①治疗后两组中医证候积分均有显著降低。治疗组有效率高于对照组,P0.05；②治疗组对心绞痛症状有效率高于对照组,P0.05；治疗组与对照组对心电图影响无显著性差异,P0.05；③治疗后两组Lp-PLA2、hs-CRP均较治疗前下降,P0.05；治疗组Lp-PLA2、 hs-CRP水平降低幅度更大,P0.05；④两组患者治疗后TC、LDL-C均较前下降,P0.05；TG、HDL-C水平较前变化不显著,P0.05；治疗组TC、LDL-C降低幅度更大,P0.05,两组TG、HDL-C水平无显著性差异,P0.05。结论：1.大株红景天注射液可以改善心血瘀阻型稳定性心绞痛患者的临床症状；2.在西医常规治疗基础上加用大株红景天注射液能有效降低冠心病患者的Lp-PLA2及hs-CRP水平；3.大株红景天注射液对稳定性心绞痛患者具有良好的药物安全性。
[Abstract]:Objective: to observe the therapeutic effect of large strain Rhodiola injection on patients with stable angina pectoris and its effect on lipoprotein associated phospholipase A2 (PLA2). Lipoprotein correlation phospholipase A2. Lp-PLA2) and hypersensitive C-reactive protein (hs-CRP). To explore the therapeutic effect of Rhodiola on stable angina pectoris and whether its mechanism is related to inflammatory factors. Methods: 80 patients who met the inclusion criteria were randomly divided into treatment group and control group. 40 cases in each group. The control group was given routine treatment for coronary heart disease. 40 cases in the treatment group were given 10m1 large Rhodiola injection diluted with 5% glucose injection 250ml intravenous drip on the basis of routine treatment. Once a day for 14 days; The changes of TCM syndromes, symptoms of angina pectoris, ECG, Lp-PLA2 and hs-CRP, blood lipid, liver and kidney function were observed and compared before and after treatment. Lp-PLA2 and hs-CRP were measured by colorimetric method and immune turbidimetric method respectively. Results the scores of TCM syndromes in the two groups were significantly decreased after treatment with 1: 1. The effective rate of the treatment group was higher than that of the control group. P0.05; 2the effective rate of angina pectoris in the treatment group was higher than that in the control group (P 0.05); There was no significant difference in electrocardiogram between the treatment group and the control group (P 0.05). 3After treatment, the levels of Lp-PLA2hs-CRP in the two groups were lower than those before treatment (P 0.05); In the treatment group, the level of Lp-PLA2 and hs-CRP decreased more significantly (P0.05). (4) after treatment, the LDL-C levels of TCU in both groups were significantly lower than those in the former group (P 0.05); The level of HDL-C in TGN had no significant change (P0.05). The decrease of LDL-C in the treatment group was greater than that in the control group (P0.05). There was no significant difference in the level of HDL-C between the two groups. Conclusion 1. Large strain of Rhodiola injection can improve the clinical symptoms of patients with stable angina pectoris of blood stasis type. 2. On the basis of routine western medicine treatment, the levels of Lp-PLA2 and hs-CRP in patients with coronary heart disease can be effectively reduced by adding DZRI; 3. Large strain Rhodiola injection has good drug safety for stable angina pectoris patients.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R541.4

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